سعر جاسبرومين 1000 مجم 100 قرص 2022

Metformin hydrochloride 1000 mg extended-release film-coated tablets, an oral biguanide for type 2 diabetes.

• Adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus.Population: AdultsDailyMed (U.S. National Library of Medicine)

• In a trial with glyburide, reactions in more than 5% and more frequent than placebo: hypoglycaemia (14%), diarrhoea (13%) and nausea (7%).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Severe renal impairment (eGFR below 30 mL/min/1.73 m2).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to metformin.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - lactic acidosis: postmarketing cases, some fatal. Risk factors include renal impairment, carbonic anhydrase inhibitors (e.g. topiramate), age 65 or older, contrast studies, surgery, hypoxic states (e.g. acute heart failure), excess alcohol, hepatic impairment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Vitamin B12 deficiency (subnormal levels in about 7% of patients in trials); measure haematological parameters annually and vitamin B12 every 2-3 years.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hypoglycaemia risk increases with insulin or insulin secretagogues; lower doses of these may be needed.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Carbonic anhydrase inhibitors (e.g. topiramate)May increase the risk of lactic acidosis.DailyMed (U.S. National Library of Medicine)
• Iodinated contrast agentsDiscontinue metformin at or before the imaging procedure in at-risk patients; re-evaluate eGFR after 48 hours.DailyMed (U.S. National Library of Medicine)
• Insulin and insulin secretagoguesIncreased risk of hypoglycaemia; dose reduction may be needed.DailyMed (U.S. National Library of Medicine)

• Limited data are not sufficient to determine a drug-associated risk; published studies have not reported a clear association between metformin and major birth defects or miscarriage. Poorly controlled diabetes carries maternal and fetal risks.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Metformin is present in human milk in limited published studies; effects on the breastfed infant are insufficiently known. Weigh benefits of breastfeeding against the mother's need.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Metformin hydrochloride: Decreases hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity by increasing peripheral glucose uptake and utilisation; insulin secretion is unchanged.