سعر ابو-ديسموبريسين 10 مايكرو سبراي 2.5 مل 2022

Desmopressin acetate 10 mcg per dose nasal spray, 2.5 ml bottle (antidiuretic vasopressin analogue); Apotex Inc. (Canada), Egyptian Pharmex.

• Antidiuretic replacement therapy in the management of central diabetes insipidus in adults and paediatric patients 4 years and older. Not indicated for nephrogenic diabetes insipidus or primary nocturnal enuresis.Population: Adults; paediatric patients >=4 yearsDailyMed (U.S. National Library of Medicine)

• Post-approval reports: increased blood pressure, headache, nasal congestion, rhinitis, nosebleed, sore throat, cough, upper respiratory infections, nausea, flushing, abdominal cramps, hyponatraemia (including hyponatraemic convulsions) and severe allergic reactions.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to desmopressin acetate or any component; renal impairment with CLcr <50 mL/min; hyponatraemia or a history of hyponatraemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hyponatraemia/water intoxication, which can be fatal (seizures, coma, respiratory arrest); restrict fluid intake and watch for headache, nausea, weight gain, confusion and other signs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Nasal mucosal changes (scarring, oedema, atrophy, congestion, recent nasal surgery) may cause erratic absorption; avoid intranasal use in such patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Drugs that may increase the risk of hyponatraemia (e.g. tricyclic antidepressants, SSRIs, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine, oxybutynin, carbamazepine)Increased risk of water intoxication with hyponatraemia; monitor serum sodium more frequently.DailyMed (U.S. National Library of Medicine)
• Other vasoconstrictorsDesmopressin can raise blood pressure; large doses with other vasoconstrictors may require dose reduction.DailyMed (U.S. National Library of Medicine)

• Decades of published experience in pregnancy did not identify a drug-associated risk of major birth defects, miscarriage or adverse maternal/fetal outcomes; placental transfer is poor.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Poorly transferred into breast milk at negligible amounts; clinically relevant infant exposure is not expected after maternal intranasal use.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Desmopressin: Synthetic analogue of arginine vasopressin with enhanced antidiuretic activity and reduced vasopressor and visceral smooth-muscle effects (US label).