سعر بريفافيوتال 100 مجم 2024

Brivafutal 100 mg film-coated tablets ×30 (FPI). Brivaracetam for partial-onset seizures (per US Briviact same strength).

• Treatment of partial-onset seizures in patients 1 month of age and older (monotherapy or adjunctive).Population: Patients ≥1 month (weight-based dosing <16 y)DailyMed / FDA

• Adults most common (≥5% and ≥2% more than placebo): somnolence/sedation, dizziness, fatigue, nausea/vomiting.International label, same formulation · DailyMed / FDA

• Hypersensitivity to brivaracetam or any inactive ingredient (bronchospasm and angioedema have occurred).International label, same formulation · DailyMed / FDA

• Suicidal behavior and ideation: AEDs increase risk; monitor for depression/suicidality.International label, same formulation · DailyMed / FDA
• Neurological adverse reactions: somnolence, fatigue, dizziness, gait/coordination disturbance — caution driving.International label, same formulation · DailyMed / FDA
• Psychiatric adverse reactions: irritability, anxiety, aggression, psychotic symptoms — monitor.International label, same formulation · DailyMed / FDA

• RifampinMajorDecreases brivaracetam levels — increase Briviact dose by up to 100% while on rifampin.DailyMed / FDA
• CarbamazepineModerateMay increase carbamazepine-epoxide; consider reducing carbamazepine if tolerability issues.DailyMed / FDA
• PhenytoinModerateBrivaracetam can increase phenytoin concentrations — monitor levels.DailyMed / FDA

• Available human data insufficient to identify risk of major birth defects/miscarriage. Animal data: developmental toxicity at exposures above clinical. May cause fetal harm based on animal data. Enroll in NAAED pregnancy registry.International label, same formulation · DailyMed / FDA
• Brivaracetam is present in human milk. Weigh benefits of breastfeeding against clinical need and potential infant effects.International label, same formulation · DailyMed / FDA

• Brivaracetam: High selective affinity for SV2A; precise anticonvulsant mechanism not fully established.