سعر كلاتكس 75 مجم 30 قرص مغلف 2024

Clatex 75 mg film-coated tablets, 30 tablets (clopidogrel). EGPI. Antiplatelet P2Y12 inhibitor.

• Reduce rate of MI and stroke in patients with non-ST-elevation ACS (UA/NSTEMI), including medically managed and revascularized patients; use with aspirin (US PLAVIX).Population: Adults with ACSDailyMed (U.S. National Library of Medicine)
• Reduce rate of MI and stroke in STEMI managed medically; use with aspirin.Population: Adults with STEMIDailyMed (U.S. National Library of Medicine)
• Reduce rate of MI and stroke in recent MI, recent stroke, or established peripheral arterial disease.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Active pathological bleeding (e.g., peptic ulcer or intracranial hemorrhage); hypersensitivity to clopidogrel or product components.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: diminished effect in CYP2C19 poor metabolizers; consider alternative P2Y12 inhibitor. Avoid omeprazole/esomeprazole. Bleeding risk; premature discontinuation increases CV events; rare TTP reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Omeprazole / esomeprazoleMajorAvoid concomitant use: significantly reduce antiplatelet activity of clopidogrel via CYP2C19 inhibition.DailyMed (U.S. National Library of Medicine)
• NSAIDs / warfarin / SSRIs / SNRIs / other antiplateletsMajorIncrease bleeding risk (additive effects on hemostasis).DailyMed (U.S. National Library of Medicine)

• Available data have not identified drug-associated risks of major birth defects or miscarriage; MI/stroke are emergencies — do not withhold therapy solely for pregnancy concerns (US PLAVIX).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; present in rat milk. Weigh benefits of breastfeeding against maternal need.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Clopidogrel: Prodrug converted (mainly via CYP2C19) to an active metabolite that irreversibly blocks the platelet P2Y12 ADP receptor for the platelet lifespan.