سعر كوفيرام 5/10 مجم 15 قرص 2024

Fixed-dose combination of perindopril arginine 5 mg and amlodipine 10 mg; 15 tablets (Servier, Egypt).

• Substitution therapy for essential hypertension and/or stable coronary artery disease in patients already controlled on concurrent perindopril and amlodipine at the same dose levels.Population: AdultsServier (regional SmPC)

• Most common with components: oedema (very common with amlodipine), somnolence, dizziness, headache, dysgeusia, paraesthesia, visual impairment, tinnitus, vertigo, palpitations, flushing, hypotension, dyspnoea, cough, abdominal pain, nausea, vomiting, dyspepsia, diarrhoea, constipation, pruritus, rash, ankle swelling, muscle spasms, fatigue, asthenia.International label, same formulation · Servier (regional SmPC)

• Hypersensitivity to perindopril, other ACE inhibitors, amlodipine, dihydropyridines, or excipients; history of ACE-inhibitor angioedema; hereditary/idiopathic angioedema; 2nd/3rd trimester pregnancy; aliskiren in diabetes or renal impairment; sacubitril/valsartan within 36 h; significant bilateral renal artery stenosis; severe hypotension, shock, left-ventricular outflow obstruction, haemodynamically unstable heart failure after acute MI.International label, same formulation · Servier (regional SmPC)

• Risk of angioedema (including intestinal); higher in Black patients. Monitor BP, renal function and potassium. Dual RAAS blockade not recommended. Hyperkalaemia risk with potassium-sparing agents. ACE-inhibitor cough. Caution in volume depletion, renovascular disease, collagen vascular disease, hepatic impairment, heart failure (amlodipine). Contains lactose.International label, same formulation · Servier (regional SmPC)

• Aliskiren / ARBs / sacubitril–valsartanMajorDual RAAS blockade increases hypotension, hyperkalaemia and renal failure risk; aliskiren contraindicated in diabetes/renal impairment; sacubitril/valsartan contraindicated within 36 h of perindopril.Servier (regional SmPC)
• Potassium-sparing diuretics / potassium supplementsMajorAdditive hyperkalaemia risk; avoid or monitor potassium closely.Servier (regional SmPC)
• NSAIDs including COX-2 inhibitorsModerateMay attenuate antihypertensive effect and worsen renal function; hydrate and monitor renal function.Servier (regional SmPC)

• Not recommended in 1st trimester; contraindicated in 2nd and 3rd trimesters (ACE-inhibitor fetotoxicity: oligohydramnios, renal failure, skull hypoplasia, hypotension). Not recommended during lactation.International label, same formulation · Servier (regional SmPC)
• Perindopril: no human milk data — not recommended. Amlodipine excreted in human milk (infant exposure estimate 3–7%, max 15%); decide whether to discontinue nursing or the drug.International label, same formulation · Servier (regional SmPC)

• Perindopril (as perindopril arginine): Inhibits angiotensin-converting enzyme, reducing conversion of angiotensin I to the vasoconstrictor angiotensin II and the degradation of bradykinin.
• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.