سعر ابيسوفير 400 مجم 28 قرص 2022

Sofosbuvir 400 mg film-coated tablets, 28 tablets (Eipico).

• Treatment of adults with genotype 1, 2, 3 or 4 chronic HCV infection without cirrhosis or with compensated cirrhosis, as a component of a combination antiviral regimen.Population: AdultsDailyMed (U.S. NLM)
• Treatment of pediatric patients 3 years and older with genotype 2 or 3 chronic HCV without cirrhosis or with compensated cirrhosis, in combination with ribavirin.Population: Pediatric patients >=3 yearsDailyMed (U.S. NLM)

• Most common adverse reactions (>=20%) with sofosbuvir plus ribavirin: fatigue and headache.International label, same formulation · DailyMed (U.S. NLM)

• When used in combination with ribavirin or peginterferon alfa/ribavirin, the contraindications applicable to those agents apply to the combination therapy.International label, same formulation · DailyMed (U.S. NLM)

• Boxed warning: risk of hepatitis B virus reactivation in HCV/HBV coinfected patients, in some cases resulting in fulminant hepatitis, hepatic failure and death; test all patients for HBsAg and anti-HBc before starting treatment.International label, same formulation · DailyMed (U.S. NLM)
• Serious symptomatic bradycardia may occur when sofosbuvir is coadministered with amiodarone, particularly in patients also receiving beta-blockers or with underlying cardiac comorbidities; coadministration is not recommended.International label, same formulation · DailyMed (U.S. NLM)

• AmiodaroneCoadministration not recommended due to risk of serious symptomatic bradycardia.DailyMed (U.S. NLM)

• If sofosbuvir is administered with ribavirin or peginterferon/ribavirin, the combination regimen is contraindicated in pregnant women and in men whose female partners are pregnant.International label, same formulation · DailyMed (U.S. NLM)
• It is not known whether sofosbuvir and its metabolites are present in human milk; consider the benefits of breastfeeding with the mother's clinical need and potential adverse effects.International label, same formulation · DailyMed (U.S. NLM)

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