سعر هيتيروسوفير 400 مجم 28 اقراص 2022

Sofosbuvir 400 mg tablets, pack of 28 (Pharmamed Healthcare, Egypt).

• Chronic hepatitis C (genotype 1, 2, 3 or 4) without cirrhosis or with compensated cirrhosis, as a component of a combination antiviral regimenPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse events (≥ 20%): with ribavirin—fatigue and headache; with peginterferon alfa and ribavirin—fatigue, headache, nausea, insomnia and anaemia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• When used with ribavirin or peginterferon alfa/ribavirin, the contraindications of those agents apply to the combination.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: test all patients for current or prior hepatitis B infection before starting; HBV reactivation, sometimes fulminant hepatitis, hepatic failure and death, has been reported in HCV/HBV coinfected patients.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Serious symptomatic bradycardia may occur with amiodarone and a sofosbuvir-containing regimen; coadministration not recommended; cardiac monitoring if no alternative.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• AmiodaroneSerious symptomatic bradycardia, particularly with beta blockers, cardiac comorbidities and/or advanced liver disease; coadministration not recommended.DailyMed (U.S. National Library of Medicine)

• Combination with ribavirin (± peginterferon alfa) is contraindicated in pregnant women and in men whose female partners are pregnant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• No adequate human data on sofosbuvir alone; no adverse developmental outcomes in animal studies at exposures above human exposure.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether sofosbuvir or its metabolites are present in human milk; the main metabolite was found in rat milk without effect on pups; weigh benefits of breastfeeding against maternal need.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

English text not available for this section.