سعر جيفاروروك 10/20 مجم 14 قرص 2022

Film-coated tablets of ezetimibe 10 mg with simvastatin 20 mg, pack of 14, by EGPI / People Pharma (also associated with Chemedica in secondary listings). Lipid-lowering fixed-dose combination.

• Adjunct to diet to reduce elevated LDL-C in primary hyperlipidemia and in heterozygous familial hypercholesterolemia; also used with other lipid-lowering treatments in homozygous familial hypercholesterolemia (US Vytorin labelling).Population: AdultsDailyMed (NLM)

• Common adverse reactions for the combination include headache, myalgia, upper respiratory infection, and gastrointestinal symptoms (per US labelling).International label, same formulation · DailyMed (NLM)

• Concomitant use of strong CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, boceprevir, telaprevir, nefazodone), cobicistat-containing products, cyclosporine, danazol or gemfibrozil.International label, same formulation · DailyMed (NLM)
• Active liver disease or unexplained persistent elevations of hepatic transaminases.International label, same formulation · DailyMed (NLM)
• Pregnancy and lactation (US Vytorin contraindication section for the combination).International label, same formulation · DailyMed (NLM)

• Myopathy/rhabdomyolysis risk with simvastatin component; risk increases with higher doses and interacting drugs; discontinue if markedly elevated CK or myopathy diagnosed.International label, same formulation · DailyMed (NLM)
• Liver enzyme abnormalities; perform liver enzyme tests before initiating therapy and thereafter when clinically indicated.International label, same formulation · DailyMed (NLM)
• Immune-mediated necrotizing myopathy (IMNM) reported with statins.International label, same formulation · DailyMed (NLM)

• Discontinue when pregnancy is recognized (or consider ongoing therapeutic needs); cholesterol-lowering treatment is generally not necessary during pregnancy and may cause fetal harm by decreasing cholesterol synthesis (US).International label, same formulation · DailyMed (NLM)
• Breastfeeding is contraindicated / not recommended while using ezetimibe/simvastatin (US).International label, same formulation · DailyMed (NLM)

• Ezetimibe: Reduces intestinal absorption of cholesterol and related phytosterols at the brush border of the small intestine.
• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis.