سعر جليفلوزاميت إكس آر 12.5/1000 مجم 30 قرص 2024

Empagliflozin 12.5 mg + metformin 1000 mg XR film-coated tablets, 30s, Marcyrl (Egypt).

• Treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise, as monotherapy when metformin is inappropriate, or in addition to other antidiabetic medicinal products (empagliflozin (with metformin), SGLT2 inhibitor).Population: Adults with type 2 diabetesDailyMed (U.S. National Library of Medicine)

• Very common/common: genital mycotic infections, UTI, increased urination, thirst, volume depletion–related events; rare: DKA; not known: Fournier gangrene (class).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to empagliflozin (with metformin) or excipients. Do not use in type 1 diabetes. Discontinue if eGFR falls persistently below the labeled cut-off; not for ESRD/dialysis where ineffective.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Diabetic ketoacidosis (including euglycaemic DKA) — interrupt for major surgery/acute illness; assess ketones if suggestive symptoms occur regardless of glucose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Volume depletion/hypotension, genital mycotic infections, UTI, Fournier gangrene risk, lower-limb amputation counselling, and reduced glycaemic efficacy in moderate–severe renal impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Metformin component: lactic acidosis risk; assess GFR before/during therapy; stop for contrast, hypoxia, dehydration, and surgery as labeled for metformin FDCs.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• DiureticsModerateMay add to diuretic effect and increase dehydration/hypotension risk.DailyMed (U.S. National Library of Medicine)
• Insulin / sulfonylureasModerateMay increase hypoglycaemia risk — consider lower secretagogue/insulin dose.DailyMed (U.S. National Library of Medicine)

• empagliflozin (with metformin) should not be used during pregnancy (animal data suggest possible effects on renal development/maturation).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Do not use empagliflozin (with metformin) during breastfeeding; excreted in animal milk and a risk to the newborn/infant cannot be excluded.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Empagliflozin: Inhibits SGLT2, increasing urinary glucose excretion.
• Metformin: Decreases hepatic glucose production and improves insulin sensitivity.