سعر هارفوني 90/400 مجم 28 قرص 2022

Ledipasvir 90 mg / sofosbuvir 400 mg tablets, pack of 28, Gilead Sciences product listed in Egypt; fixed-dose direct-acting antiviral for chronic hepatitis C.

• Chronic hepatitis C genotype 1, 4, 5 or 6 without cirrhosis or with compensated cirrhosis; genotype 1 with decompensated cirrhosis (with ribavirin); genotype 1 or 4 liver-transplant recipients (with ribavirin).Population: Adults and pediatric patients 3 years and olderDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (at least 10%, all grades) in adults: fatigue, headache and asthenia.International label, same product · DailyMed (U.S. National Library of Medicine)

• If used with ribavirin, all contraindications to ribavirin also apply to the combination regimen.International label, same product · DailyMed (U.S. National Library of Medicine)

• Boxed warning: hepatitis B virus reactivation, sometimes resulting in fulminant hepatitis, hepatic failure and death, has occurred in HCV/HBV co-infected patients; test all patients for current or prior HBV infection before starting.International label, same product · DailyMed (U.S. National Library of Medicine)
• Serious symptomatic bradycardia may occur with amiodarone coadministration, particularly with beta-blockers or underlying heart disease; coadministration is not recommended, and cardiac monitoring is needed if unavoidable.International label, same product · DailyMed (U.S. National Library of Medicine)
• P-gp inducers such as rifampin and St John's wort may significantly decrease ledipasvir and sofosbuvir concentrations; use is not recommended.International label, same product · DailyMed (U.S. National Library of Medicine)

• AmiodaroneRisk of serious symptomatic bradycardia; coadministration not recommended.DailyMed (U.S. National Library of Medicine)
• Antacids (aluminium/magnesium hydroxide)Reduce ledipasvir solubility and concentrations; separate administration by 4 hours.DailyMed (U.S. National Library of Medicine)
• H2-receptor antagonists and proton-pump inhibitorsReduce ledipasvir concentrations; H2 blockers at doses up to famotidine 40 mg twice daily may be given simultaneously or 12 hours apart; PPIs at doses up to omeprazole 20 mg simultaneously under fasted conditions.DailyMed (U.S. National Library of Medicine)

• No adequate human data; no adverse developmental outcomes in animal studies with ledipasvir or sofosbuvir at exposures above human levels. If given with ribavirin, the regimen is contraindicated in pregnant women and in men whose female partners are pregnant.International label, same product · DailyMed (U.S. National Library of Medicine)
• Unknown whether ledipasvir, sofosbuvir or their metabolites are present in human milk; ledipasvir and the main sofosbuvir metabolite were found in rat milk without clear effects on pups.International label, same product · DailyMed (U.S. National Library of Medicine)

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