سعر هيباتوفيرين 400 مجم 30 كبسولة 2022

Ribavirin 400 mg capsules (Mepaco / Egypharma), pack of 30 capsules.

• Chronic hepatitis C in patients 3 years and older with compensated liver disease, in combination with interferon alfa-2b (pegylated or non-pegylated); ribavirin monotherapy is not effective.DailyMed (U.S. National Library of Medicine)

• The primary toxicity is haemolytic anaemia, with haemoglobin reductions in the first 1-2 weeks; cardiac and pulmonary reactions associated with anaemia occurred in about 10% of patients in combination therapy trials.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Pregnancy (women who are pregnant or planning pregnancy) and men whose female partners are pregnant.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis or erythema multiforme to ribavirin; autoimmune hepatitis; haemoglobinopathies (e.g. thalassaemia major, sickle-cell anaemia); creatinine clearance below 50 mL/min; co-administration with didanosine.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning: embryo-fetal toxicity (see pregnancy); haemolytic anaemia, which may worsen cardiac disease and has led to fatal and non-fatal myocardial infarction (avoid in significant or unstable cardiac disease); ribavirin monotherapy is not effective for chronic hepatitis C.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Haemolytic anaemia occurred in about 10% of ribavirin/interferon-treated subjects, within 1-2 weeks of starting; assess for cardiac disease before treatment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Pancytopenia and bone marrow suppression reported with pegylated interferon/ribavirin plus azathioprine; discontinue all three and do not reintroduce.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• DidanosineIncreased exposure to didanosine or its active metabolite with risk of fatal hepatic failure, peripheral neuropathy, pancreatitis and lactic acidosis; co-administration contraindicated.DailyMed (U.S. National Library of Medicine)
• Nucleoside reverse transcriptase inhibitors (HIV/HCV co-infection)Hepatic decompensation (some fatal) in cirrhotic co-infected patients receiving antiretrovirals with interferon and ribavirin; monitor closely for hepatic decompensation and anaemia.DailyMed (U.S. National Library of Medicine)
• AzathioprineRibavirin inhibits IMP dehydrogenase, causing accumulation of a myelotoxic azathioprine metabolite (severe pancytopenia); monitor complete blood counts weekly in the first month.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnant women and in men whose female partners are pregnant; significant teratogenic and embryocidal effects in all animal species tested; multiple-dose half-life about 12 days and may persist up to 6 months in non-plasma compartments.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

English text not available for this section.