سعر بانفيرين 200 مجم 10 كبسول 2022

Panvirin ribavirin 200 mg capsules, pack of 10, by Alfacure Pharmaceuticals (Egypt); nucleoside analogue antiviral.

• Chronic hepatitis C in patients 3 years and older with compensated liver disease, in combination with interferon alfa-2b (pegylated or non-pegylated); not for monotherapyPopulation: Patients >=3 yearsDailyMed (U.S. National Library of Medicine)

• Pregnancy, women planning pregnancy, and men whose female partners are pregnant.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Autoimmune hepatitis, hemoglobinopathies (e.g. thalassemia major, sickle-cell anemia), creatinine clearance <50 mL/min, and co-administration with didanosine (per US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: significant teratogenic/embryocidal effects; negative pregnancy test before starting and effective contraception during treatment and for 9 months (women) / 6 months (male patients' partners) afterwards.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: hemolytic anemia (about 10% with interferon combination) usually within 1-2 weeks; may worsen cardiac disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: ribavirin monotherapy is not effective for chronic hepatitis C.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• DidanosineContraindicated: fatal hepatic failure, peripheral neuropathy, pancreatitis and symptomatic hyperlactatemia/lactic acidosis reported.DailyMed (U.S. National Library of Medicine)

• US label: contraindicated in pregnant women and in men whose female partners are pregnant; animal data show teratogenic and embryocidal effects; ribavirin persists in non-plasma compartments for up to 6 months.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• US label: no data on presence in human milk or effects on the breastfed infant; weigh benefits of breastfeeding against the mother's need and potential infant risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ribavirin: Synthetic purine nucleoside analogue with direct activity against many RNA viruses in cell culture; increases viral mutation frequency and its triphosphate inhibits HCV polymerase; clinical mechanism not fully understood (US label 12.4).