سعر جينيدوفير 90/400 مجم 28 قرص 2022

Ledipasvir 90 mg / sofosbuvir 400 mg tablets, pack of 28, listed in Egypt under Pharmed Healthcare (Genesis Pharmaceuticals); direct-acting antiviral for chronic hepatitis C.

• Chronic hepatitis C genotype 1, 4, 5 or 6 without cirrhosis or with compensated cirrhosis; genotype 1 with decompensated cirrhosis (with ribavirin); genotype 1 or 4 liver-transplant recipients (with ribavirin). Adults and children 3 years and older.Population: Adults and pediatric patients 3 years and olderDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (10% or more): fatigue, headache and asthenia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• When used with ribavirin, the contraindications of ribavirin also apply to the combination regimen.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: hepatitis B reactivation, sometimes fulminant, has occurred in HCV/HBV co-infected patients; test all patients for HBsAg and anti-HBc before starting and monitor co-infected patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious symptomatic bradycardia, including fatal cardiac arrest, has been reported with amiodarone; coadministration is not recommended, and cardiac monitoring is required if unavoidable.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• P-gp inducers (e.g. rifampin, St John's wort) may significantly lower ledipasvir and sofosbuvir levels; use is not recommended.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• AmiodaroneRisk of serious symptomatic bradycardia; coadministration not recommended.DailyMed (U.S. National Library of Medicine)
• Antacids (aluminium/magnesium hydroxide)Lower ledipasvir concentrations; separate administration by 4 hours.DailyMed (U.S. National Library of Medicine)
• H2-receptor antagonists and proton-pump inhibitorsLower ledipasvir concentrations; H2 blockers up to famotidine 40 mg twice daily may be given simultaneously or 12 hours apart; PPIs up to omeprazole 20 mg simultaneously under fasted conditions.DailyMed (U.S. National Library of Medicine)

• No adequate human data; no adverse developmental outcomes in animal studies at exposures above human levels. With ribavirin, the regimen is contraindicated in pregnant women and in men whose partners are pregnant.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether ledipasvir or sofosbuvir is present in human milk; ledipasvir and the main sofosbuvir metabolite were found in rat milk without clear effects on pups.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ledipasvir:
• Sofosbuvir: Nucleotide prodrug converted intracellularly to an active uridine analogue triphosphate that is incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.