سعر هيساتروب 10مجم 30 قرص 2026

Rupatadine 10 mg film-coated tablets (Mash Premiere, Egypt), a second-generation antihistamine for allergic rhinitis and urticaria; 30 tablets.

• Symptomatic treatment of allergic rhinitis and urticaria in adults and adolescents over 12 years.Population: Adults and adolescents >12 yearsElectronic Medicines Compendium (eMC, UK)

• Most common in trials: somnolence (9.4%), headache (6.9%), fatigue (3.1%), asthenia (1.5%), dry mouth (1.2%) and dizziness (1.0%); mostly mild to moderate.International label, same formulation · Electronic Medicines Compendium (eMC, UK)

• Hypersensitivity to rupatadine or to any of the excipients.International label, same formulation · Electronic Medicines Compendium (eMC, UK)

• Avoid grapefruit juice and potent CYP3A4 inhibitors; use moderate CYP3A4 inhibitors with caution. Dose adjustment of sensitive or narrow-therapeutic-index CYP3A4 substrates (e.g. simvastatin, ciclosporin, tacrolimus) may be required.International label, same formulation · Electronic Medicines Compendium (eMC, UK)
• Although a thorough QT study showed no ECG effect up to 10 times the therapeutic dose, use with caution in known QT prolongation, uncorrected hypokalaemia or ongoing proarrhythmic conditions.International label, same formulation · Electronic Medicines Compendium (eMC, UK)

• Ketoconazole, erythromycin and other CYP3A4 inhibitorsRupatadine exposure increased about 10-fold with ketoconazole and 2-3-fold with erythromycin; avoid potent inhibitors and use moderate inhibitors with caution.Electronic Medicines Compendium (eMC, UK)
• Grapefruit juiceIncreased rupatadine exposure 3.5-fold; should not be taken at the same time.Electronic Medicines Compendium (eMC, UK)
• Alcohol and CNS depressantsRupatadine 20 mg increased alcohol-induced impairment; interactions with CNS depressants cannot be excluded.Electronic Medicines Compendium (eMC, UK)

• Limited human data; animal studies do not indicate harm. As a precaution, it is preferable to avoid rupatadine during pregnancy.International label, same formulation · Electronic Medicines Compendium (eMC, UK)
• Excreted in animal milk; unknown in human milk. Decide whether to stop breast-feeding or abstain from therapy, weighing benefits.International label, same formulation · Electronic Medicines Compendium (eMC, UK)

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