سعر انهيبازون 25/15مجم 30 قرص 2026

Inhibazone 25/15 mg (Hikma Pharma): tablets of alogliptin 25 mg (DPP-4 inhibitor) with pioglitazone 15 mg (thiazolidinedione), 30 tablets.

• Adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=4%): nasopharyngitis, back pain and upper respiratory tract infection.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity to alogliptin or pioglitazone (anaphylaxis, angioedema, severe skin reactions). Do not initiate in patients with established NYHA class III or IV heart failure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• EU SmPC: contraindicated in patients with cardiac failure or a history of cardiac failure (NYHA class I to IV).General active-ingredient information · European Medicines Agency (EMA)

• Boxed warning - congestive heart failure: thiazolidinediones including pioglitazone cause or worsen heart failure; observe for signs (weight gain, oedema, dyspnoea) and manage or discontinue; not recommended in symptomatic heart failure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Acute pancreatitis; serious hypersensitivity; hepatic effects (check liver tests, interrupt if injury); oedema; increased fracture incidence in women; possible bladder cancer risk (avoid in active bladder cancer); hypoglycaemia with insulin or secretagogues; macular oedema; severe arthralgia; bullous pemphigoid.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP2C8 inhibitors (e.g. gemfibrozil)Increase pioglitazone exposure; the pioglitazone dose should not exceed 15 mg daily.DailyMed (U.S. National Library of Medicine)
• Insulin or insulin secretagoguesIncreased risk of hypoglycaemia; a lower dose of insulin or secretagogue may be needed.DailyMed (U.S. National Library of Medicine)

• Limited data with alogliptin/pioglitazone or its components in pregnancy are insufficient to inform drug-associated risk; poorly controlled diabetes carries maternal and fetal risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on alogliptin or pioglitazone in human milk (both present in rat milk); weigh breastfeeding benefits against the mother's need for the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Alogliptin: Inhibits DPP-4, slowing inactivation of incretin hormones (GLP-1, GIP) and so increasing glucose-dependent insulin release and lowering glucagon.
• Pioglitazone: PPAR-gamma agonist that decreases insulin resistance in peripheral tissues and liver, increasing insulin-dependent glucose disposal and reducing hepatic glucose output.