سعر نيترولينجوال 0.4مجم/جرعة بخاخ للفم 2022

Nitrolingual 0.4 mg/dose oral (lingual) pump spray (nitroglycerin; G. Pohl-Boskamp, Germany, marketed by Sunny Medical in Egypt) for acute angina attacks and prophylaxis.

• Acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery diseasePopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>2%): headache, dizziness, paraesthesia. Post-marketing: weakness, drowsiness, flushing, rash, hypotension, syncope.International label, same product · DailyMed (U.S. National Library of Medicine)

• Use of PDE-5 inhibitors (avanafil, sildenafil, tadalafil, vardenafil) or riociguat; severe anaemia; increased intracranial pressure; hypersensitivity to nitroglycerin, other nitrates/nitrites or excipients.International label, same product · DailyMed (U.S. National Library of Medicine)

• Excessive use may lead to tolerance. Severe hypotension (especially upright) may occur even with small doses, particularly with constrictive pericarditis, aortic or mitral stenosis, volume depletion or existing hypotension; may be accompanied by paradoxical bradycardia. May aggravate angina of hypertrophic obstructive cardiomyopathy. Dose-related headaches.International label, same product · DailyMed (U.S. National Library of Medicine)

• PDE-5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil)Contraindicated: PDE-5 inhibitors amplify the vasodilatory effect of nitrates and can cause severe hypotension, syncope or myocardial ischaemia.DailyMed (U.S. National Library of Medicine)
• Riociguat (soluble guanylate cyclase stimulator)Contraindicated: concomitant use can cause hypotension.DailyMed (U.S. National Library of Medicine)
• Antihypertensives and beta-blockersPossible additive hypotensive effects; observe patients.DailyMed (U.S. National Library of Medicine)

• Limited published data are insufficient to determine a drug-associated risk of major birth defects or miscarriage; no adverse developmental effects in animal studies.International label, same product · DailyMed (U.S. National Library of Medicine)
• Not studied in lactating women; unknown whether present in milk. Consider benefits of breastfeeding with the mother's clinical need.International label, same product · DailyMed (U.S. National Library of Medicine)

• Nitroglycerin (glyceryl trinitrate): Nitroglycerin forms nitric oxide, which activates guanylate cyclase and raises cyclic GMP in vascular smooth muscle, causing vasodilatation (venous more than arterial) (US Nitrolingual label 12.1).