سعر فلوكازونيل 25 مجم / 5 مل شراب 70 مل 2022

Fluconazole 25 mg/5 ml oral syrup, a triazole antifungal.

• Children 0-17 years: mucosal candidiasis (oropharyngeal, oesophageal), invasive candidiasis, cryptococcal meningitis and prophylaxis of candidal infections in immunocompromised patients.Population: Children 0-17 yearsemc (medicines.org.uk)
• Adults: cryptococcal meningitis, coccidioidomycosis, invasive and mucosal candidiasis, vaginal candidiasis and dermatomycoses, and related prophylaxis.Population: Adultsemc (medicines.org.uk)

• Hypersensitivity to fluconazole, related azoles or any excipient.International label, equivalent formulation · emc (medicines.org.uk)
• Co-administration of terfenadine (with multiple fluconazole doses of 400 mg/day or more) and of other QT-prolonging drugs metabolised by CYP3A4 such as cisapride, astemizole, pimozide, quinidine and erythromycin.International label, equivalent formulation · emc (medicines.org.uk)

• Rare serious hepatotoxicity, including fatalities, has occurred mainly in patients with serious underlying disease; monitor liver tests and stop if clinical signs of liver disease develop.International label, equivalent formulation · emc (medicines.org.uk)
• Fluconazole can prolong the QT interval; use with caution in patients with potentially proarrhythmic conditions.International label, equivalent formulation · emc (medicines.org.uk)
• Exfoliative skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) and DRESS have been reported; anaphylaxis is rare. Use with caution in renal dysfunction.International label, equivalent formulation · emc (medicines.org.uk)

• Drugs metabolised by CYP2C9, CYP2C19 and CYP3A4Fluconazole is a moderate CYP2C9 and CYP3A4 inhibitor and a strong CYP2C19 inhibitor; monitor patients taking narrow-therapeutic-index drugs metabolised by these enzymes (e.g. warfarin, phenytoin, ciclosporin).emc (medicines.org.uk)

• Observational studies suggest an increased risk of spontaneous abortion with fluconazole in the first and/or second trimester; first-trimester exposure has been associated with small increases in musculoskeletal and possibly cardiac malformations, and high doses (400-800 mg/day) for 3 months or more with a pattern of birth defects. Standard short courses should not be used in pregnancy unless clearly necessary.International label, equivalent formulation · emc (medicines.org.uk)
• Fluconazole passes into breast milk at concentrations similar to plasma; breastfeeding may continue after a single 150 mg dose but is not recommended after repeated or high doses.International label, equivalent formulation · emc (medicines.org.uk)

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