سعر جيستاميفام 10/80 مجم 10 قرص 2022

Egyptian fixed-dose tablet of ezetimibe 10 mg + simvastatin 80 mg (lipid-lowering combination) by EGPI.

• Adjunct to diet to reduce elevated LDL-C in adults with primary hyperlipidemiaDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce elevated LDL-C in adults and children 10 years and older with heterozygous familial hypercholesterolemiaDailyMed (U.S. National Library of Medicine)
• Adjunct to other LDL-C-lowering therapies in adults with homozygous familial hypercholesterolemiaDailyMed (U.S. National Library of Medicine)

• Most common (2% or more and above placebo): headache (5.8%), increased ALT (3.7%), myalgia (3.6%), upper respiratory tract infection (3.6%) and diarrhoea (2.8%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant strong CYP3A4 inhibitors (select azole antifungals, macrolide antibiotics, antivirals, nefazodone); concomitant cyclosporine or danazol; acute liver failure or decompensated cirrhosis; hypersensitivity to simvastatin, ezetimibe or excipients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• May cause myopathy and rhabdomyolysis; risk rises with higher simvastatin doses (trial incidence about 0.61% at 80 mg/day). Rare immune-mediated necrotizing myopathy; discontinue if suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serum transaminase increases have been reported; rare postmarketing fatal and non-fatal hepatic failure with statins.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Verapamil, diltiazem or dronedaroneDo not exceed 10/10 mg once daily.DailyMed (U.S. National Library of Medicine)
• Amiodarone, amlodipine or ranolazineDo not exceed 10/20 mg once daily.DailyMed (U.S. National Library of Medicine)
• LomitapideReduce dosage by 50%; do not exceed 10/20 mg once daily (10/40 mg if previously on 10/80 mg chronically).DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognized (or consider ongoing therapeutic needs); may cause fetal harm based on mechanism of action.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment (potential for serious adverse reactions in the breastfed infant).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and related phytosterols (US Vytorin label).
• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis (US Vytorin label).