سعر كارفيكس 25 مجم 30 قرص 2022

Egyptian carvedilol 25 mg tablets (Sigma), a non-selective beta-blocker with alpha-1 blocking activity.

• Mild-to-severe chronic heart failure of ischaemic or cardiomyopathic originPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Left ventricular dysfunction (LVEF 40% or less) after myocardial infarction in clinically stable patientsPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Essential hypertensionPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Heart failure/post-MI (10% or more): dizziness, fatigue, hypotension, diarrhoea, hyperglycaemia, asthenia, bradycardia, weight gain. Hypertension (5% or more): dizziness.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Bronchial asthma or related bronchospastic conditions; second- or third-degree AV block; sick sinus syndrome; severe bradycardia (without a permanent pacemaker); cardiogenic shock or decompensated heart failure requiring IV inotropes; severe hepatic impairment; history of serious hypersensitivity to carvedilol.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not stop abruptly in coronary artery disease (risk of severe angina, MI and ventricular arrhythmias); taper over 1-2 weeks. May cause bradycardia, hypotension, worsening heart failure/fluid retention; may mask hypoglycaemia symptoms and alter glucose in diabetes; avoid in non-allergic bronchospasm unless necessary.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine, propafenone)May increase carvedilol levels.DailyMed (U.S. National Library of Medicine)
• RifampinReduces carvedilol plasma concentrations by about 70%.DailyMed (U.S. National Library of Medicine)
• DigoxinDigoxin levels may increase; additive slowing of AV conduction and heart rate.DailyMed (U.S. National Library of Medicine)

• Data in pregnant women are insufficient to determine drug-associated developmental risk; poorly controlled hypertension carries maternal and fetal risks. No adverse developmental outcomes in animals at clinically relevant doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on carvedilol in human milk; present in rat milk. Weigh breastfeeding benefits against maternal need and potential infant effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Carvedilol: Blocks alpha-1, beta-1 and beta-2 adrenergic receptors.