سعر كلافوكس 1جم 14 قرص 2022

Klavox 1 g film-coated tablets (amoxicillin 875 mg + clavulanic acid 125 mg), pack of 14, made by Spimaco (Saudi Arabia) and listed in Egypt under Spimaco > EIMC. Prescription antibiotic combining a penicillin with a beta-lactamase inhibitor.

• Lower respiratory tract infections caused by beta-lactamase-producing isolates of Haemophilus influenzae and Moraxella catarrhalis.Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Acute bacterial otitis media caused by beta-lactamase-producing isolates of H. influenzae and M. catarrhalis.Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Sinusitis caused by beta-lactamase-producing isolates of H. influenzae and M. catarrhalis.Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)

• Most frequently reported: diarrhoea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%) and vaginitis (1%); diarrhoea increases with higher doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity reactions (e.g. anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactam antibacterials (penicillins, cephalosporins).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Previous cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanate.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions can occur; ask about previous penicillin, cephalosporin or other allergies before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) may occur; monitor rashes closely and discontinue if a lesion progresses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction including hepatitis and cholestatic jaundice has been reported; usually reversible, but deaths have occurred.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of amoxicillin, increasing and prolonging amoxicillin levels; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulants (e.g. warfarin)Abnormal prolongation of prothrombin time (raised INR) has been reported; monitor and adjust anticoagulant dose if needed.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcurrent use increases the incidence of rashes compared with amoxicillin alone.DailyMed (U.S. National Library of Medicine)

• Reproduction studies in rats and mice at oral doses up to 1200 mg/kg/day showed no evidence of fetal harm (US label, section 8.1); human pregnancy data are not summarised in this label.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is excreted in human milk and may lead to sensitisation of infants; use with caution in nursing women.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall synthesis; on its own it is degraded by beta-lactamases (US label, section 12.4).
• Clavulanic acid (as potassium clavulanate): Beta-lactam that inactivates some beta-lactamase enzymes, protecting amoxicillin from degradation (US label, section 12.4).