سعر ليبانتيل 145مجم 20 قرص 2024

Lipanthyl fenofibrate 145 mg film-coated tablets (nanocrystal technology), pack of 20 (Abbott); fibrate lipid-lowering agent.

• Adjunct to diet to reduce LDL-C, total-C, triglycerides and Apo B and increase HDL-C in adults with primary hypercholesterolaemia or mixed dyslipidaemia.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet in adults with severe hypertriglyceridaemia. Limitation: fenofibrate did not reduce CHD morbidity and mortality in type 2 diabetes.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Reported in more than 2% and at least 1% above placebo: abnormal liver tests, increased AST and ALT, increased CPK and rhinitis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Severe renal impairment, including dialysis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Active liver disease, including primary biliary cirrhosis and unexplained persistent liver function abnormalities.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Pre-existing gallbladder disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hepatotoxicity, including serious liver injury requiring transplantation and death: monitor ALT, AST and bilirubin at baseline and periodically; stop if liver injury develops or enzymes stay raised.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Myopathy and rhabdomyolysis, with higher risk when combined with a statin, in the elderly and in diabetes, renal failure or hypothyroidism.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Reversible serum creatinine increases; cholelithiasis; pancreatitis; hypersensitivity reactions; venous thromboembolism.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Coumarin anticoagulants (e.g. warfarin)Potentiate anticoagulation; adjust the coumarin dose to keep PT/INR at target.DailyMed (U.S. National Library of Medicine)
• StatinsIncreased risk of myopathy and rhabdomyolysis.DailyMed (U.S. National Library of Medicine)

• Limited human data are insufficient to determine risk; no embryo-fetal toxicity in animals at doses up to the maximum clinical dose; use only if the benefit justifies the risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Do not breastfeed during treatment and for 5 days after the last dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fenofibrate: Prodrug converted to fenofibric acid, which activates PPAR-alpha, increasing lipolysis and elimination of triglyceride-rich particles.