سعر لوبيد 600مجم 30 قرص 2022

Gemfibrozil 600 mg film-coated tablets, 30 tablets (Pfizer).

• Adjunctive therapy to diet for adult patients with very high serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and do not respond adequately to diet.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Reducing the risk of developing coronary heart disease only in Type IIb patients without existing coronary heart disease who have had an inadequate response to weight loss, diet, exercise and other pharmacologic agents and who have low HDL-C with elevated LDL-C and triglycerides.Population: AdultsDailyMed (U.S. National Library of Medicine)

• In the Helsinki Heart Study, reactions more frequent than placebo included dyspepsia (19.6%), abdominal pain (9.8%), acute appendicitis (1.2%) and atrial fibrillation (0.7%); diarrhea, fatigue, nausea/vomiting, eczema, rash, vertigo, constipation and headache were also reported.International label, same product · DailyMed (U.S. National Library of Medicine)

• Hepatic or severe renal dysfunction, including primary biliary cirrhosis; preexisting gallbladder disease; hypersensitivity to gemfibrozil.International label, same product · DailyMed (U.S. National Library of Medicine)
• Combination therapy with simvastatin, repaglinide, dasabuvir or selexipag.International label, same product · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk is increased when gemfibrozil is combined with HMG-CoA reductase inhibitors (statins); combination with simvastatin is contraindicated.International label, same product · DailyMed (U.S. National Library of Medicine)
• Gemfibrozil may increase cholesterol excretion into the bile and lead to cholelithiasis; discontinue if gallstones are found.International label, same product · DailyMed (U.S. National Library of Medicine)
• Concomitant warfarin: reduce warfarin dose to maintain the desired prothrombin time and monitor prothrombin frequently until stable.International label, same product · DailyMed (U.S. National Library of Medicine)

• HMG-CoA reductase inhibitors (statins); simvastatin contraindicatedIncreased risk of myopathy and rhabdomyolysis; combination with simvastatin is contraindicated.DailyMed (U.S. National Library of Medicine)
• WarfarinPotentiation of anticoagulant effect; reduce warfarin dose and monitor prothrombin time frequently.DailyMed (U.S. National Library of Medicine)
• CYP2C8 substrates (repaglinide, dasabuvir, selexipag contraindicated; enzalutamide)Gemfibrozil inhibits CYP2C8: repaglinide, dasabuvir and selexipag combinations are contraindicated; enzalutamide exposure increased 2.2-fold (seizure risk), reduce enzalutamide dose if co-administration is necessary.DailyMed (U.S. National Library of Medicine)

• There are no adequate and well-controlled studies in pregnant women; use during pregnancy only if the benefit justifies the potential risk to the fetus (adverse effects seen in animal studies).International label, same product · DailyMed (U.S. National Library of Medicine)
• Because of the potential for tumorigenicity seen in animal studies, decide whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.International label, same product · DailyMed (U.S. National Library of Medicine)

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