سعر ليب ديب 10 مجم 30 قرص 2026

Lipdip lovastatin 10 mg tablets, pack of 30 (Sigma / International Trading Office, Egypt); HMG-CoA reductase inhibitor (statin).

• Primary prevention of coronary heart disease: to reduce the risk of MI, unstable angina and coronary revascularisation in individuals without symptomatic CVD with average to moderately raised total-C/LDL-C and below-average HDL-C.Population: AdultsDailyMed (U.S. National Library of Medicine)
• To slow progression of coronary atherosclerosis in patients with coronary heart disease.Population: Adults with CHDDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce total-C and LDL-C in primary hypercholesterolaemia, and in adolescents 10-17 years with heterozygous familial hypercholesterolaemia.Population: Adults; adolescents 10-17 years with HeFHDailyMed (U.S. National Library of Medicine)

• CK elevations (at least twice normal in about 11% of patients); transaminase increases; adverse experience profile in the EXCEL study similar to placebo for most events.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Active liver disease or unexplained persistent transaminase elevations.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant strong CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, erythromycin, clarithromycin, telithromycin, nefazodone, cobicistat-containing products).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy/rhabdomyolysis (dose related, increased by drugs that raise HMG-CoA reductase inhibitory activity); advise patients to report unexplained muscle pain, tenderness or weakness and stop if myopathy is suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Persistent transaminase increases (more than 3 times ULN) occurred in about 1.9% of adults in early trials; check liver function.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitorsContraindicated (risk of myopathy/rhabdomyolysis).DailyMed (U.S. National Library of Medicine)
• Danazol, diltiazem, dronedarone, verapamilStart at 10 mg and do not exceed 20 mg/day.DailyMed (U.S. National Library of Medicine)
• AmiodaroneDo not exceed 40 mg/day.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnancy; give to women of childbearing age only when conception is highly unlikely; skeletal malformations seen in rodents at high doses; stop and reassess if pregnancy occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Contraindicated in nursing mothers.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Lovastatin: Lactone prodrug hydrolysed to the active beta-hydroxy acid, which competitively inhibits HMG-CoA reductase.