سعر ليتومين 25مجم 10 اقراص 2022

Litomen 25 mg (Egypt): miglitol 25 mg film-coated tablets, pack of 10; an oral alpha-glucosidase inhibitor that delays intestinal carbohydrate digestion, used for type 2 diabetes.

• Adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Gastrointestinal effects are the most common: flatulence (41.5% vs 12.0% placebo), diarrhoea (28.7% vs 10.0%) and abdominal pain (11.7% vs 4.7%) in US trials; diarrhoea and pain tended to diminish with continued treatment. Skin rash (4.3%) and low serum iron (9.2%) were also reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Post-marketing: ileus (including paralytic ileus), subileus, gastrointestinal pain, nausea and abdominal distension.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Diabetic ketoacidosis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or predisposition to intestinal obstruction.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Chronic intestinal diseases with marked disorders of digestion or absorption, or conditions that may deteriorate with increased intestinal gas formation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Miglitol alone should not cause hypoglycaemia, but it can increase the hypoglycaemic effect of sulfonylureas or insulin; consider reducing their dose. Treat mild-to-moderate hypoglycaemia with oral glucose (dextrose), not sucrose (cane sugar), whose breakdown is inhibited by miglitol.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Temporary loss of glycaemic control may occur with stress such as fever, trauma, infection or surgery; temporary insulin therapy may be needed.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Rare post-marketing reports of pneumatosis cystoides intestinalis have been associated with alpha-glucosidase inhibitors, including miglitol.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Intestinal adsorbents (e.g. charcoal) and carbohydrate-splitting digestive enzyme preparations (e.g. amylase, pancreatin)May reduce the effect of miglitol and should not be taken concomitantly.DailyMed (U.S. National Library of Medicine)
• Sulfonylureas or insulinAdditive blood-glucose lowering; may increase the risk of hypoglycaemia; consider reducing their dose.DailyMed (U.S. National Library of Medicine)
• Ranitidine and propranololMiglitol reduced the bioavailability of ranitidine and propranolol by 60% and 40%, respectively.DailyMed (U.S. National Library of Medicine)

• Safety in pregnant women has not been established; rat and rabbit developmental studies at multiples of the human exposure showed no fetal malformations.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Miglitol passes into human milk in very small amounts (about 0.02% of a 100 mg maternal dose), but the label recommends that it not be given to a nursing woman.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Miglitol: Reversibly inhibits membrane-bound intestinal alpha-glucoside hydrolase enzymes, delaying glucose absorption and lowering postprandial hyperglycaemia; does not enhance insulin secretion.