سعر كلوبكس اجريل 75 مجم 30 قرص 2024

Clopexagrel 75mg 30 f.c.tab: Clopidogrel 75 mg (Marcyrl Pharmaceutical Industries).

• P2Y12 platelet inhibitor indicated to reduce rate of MI and stroke in patients with acute coronary syndrome (UA/NSTEMI, STEMI; with aspirin) and in patients with recent MI, recent stroke, or established peripheral arterial disease (US Plavix label).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Active pathological bleeding (e.g. peptic ulcer, intracranial hemorrhage); hypersensitivity to clopidogrel or any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: diminished effect in CYP2C19 poor metabolizers. Avoid omeprazole/esomeprazole. Increases bleeding risk; premature discontinuation increases CV events; rare TTP; thienopyridine cross-reactivity.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Omeprazole/esomeprazole (CYP2C19 inhibitors)Reduced antiplatelet effect; avoid.DailyMed (U.S. National Library of Medicine)
• Strong CYP2C19 inducers (rifampin)Increased bleeding risk; avoid.DailyMed (U.S. National Library of Medicine)
• NSAIDs, warfarin, SSRIs/SNRIs, other antiplateletsIncreased bleeding risk.DailyMed (U.S. National Library of Medicine)

• Available data have not identified drug-associated risks of major birth defects or miscarriage; MI/stroke are medical emergencies — do not withhold needed therapy. Discontinue 5–7 days before labor/neuraxial blockade when possible (US Plavix PLLR).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Clopidogrel: Prodrug converted (mainly via CYP2C19) to an active metabolite that irreversibly blocks the platelet P2Y12 ADP receptor for the platelet lifespan.