سعر ميثوتريكسات ميلان 500مجم/20مل 10 فيال حقن 2022

Methotrexate-Mylan 500 mg/20 ml (25 mg/ml) solution for injection, pack of 10 vials (Mylan S.A.S, France; agent Ramco), a folate-analogue antimetabolite and immunosuppressant.

• Acute lymphoblastic leukaemia, as part of combination chemotherapyPopulation: Adults and paediatric patientsDailyMed (U.S. National Library of Medicine)
• Prophylaxis and treatment of meningeal leukaemiaPopulation: Adults and paediatric patientsDailyMed (U.S. National Library of Medicine)
• Non-Hodgkin lymphoma; osteosarcoma; breast cancer; squamous cell carcinoma of the head and neck; gestational trophoblastic neoplasiaDailyMed (U.S. National Library of Medicine)

• Commonly reported adverse reactions include ulcerative stomatitis, leukopenia, nausea and abdominal distress; other frequent reactions are infection, malaise, fatigue, chills, fever and dizziness.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of severe hypersensitivity to methotrexate.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Pregnancy in patients with non-neoplastic diseases.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: methotrexate can cause embryo-fetal toxicity, including fetal death; for non-neoplastic diseases it is contraindicated in pregnancy. Females and males of reproductive potential should use effective contraception.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Serious and fatal toxicities: myelosuppression, serious infections, renal toxicity, hepatotoxicity (fibrosis, cirrhosis, liver failure), neurotoxicity, gastrointestinal toxicity, pulmonary toxicity, severe dermatologic reactions, secondary malignancies and tumour lysis syndrome. Avoid live vaccines during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Medication errors have caused deaths, most often when methotrexate was taken daily instead of the prescribed weekly regimen; verify the dose and schedule.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Proton pump inhibitors, NSAIDs (including aspirin), probenecid, penicillins, sulfonamides and other highly protein-bound or antifolate drugsMay increase methotrexate exposure and the risk of severe toxicity; unexpectedly severe, sometimes fatal, gastrointestinal toxicity has occurred with NSAIDs (mainly with high-dose methotrexate). Monitor closely if co-administration cannot be avoided.DailyMed (U.S. National Library of Medicine)
• Nitrous oxide anaesthesiaPotentiates the effect of methotrexate on folate-dependent pathways and may increase severe adverse reactions; avoid nitrous oxide anaesthesia in patients receiving methotrexate.DailyMed (U.S. National Library of Medicine)
• Folic acid or folinic acid productsIn neoplastic diseases, products containing folic acid or its derivatives may decrease the effectiveness of methotrexate (avoid unless clinically indicated); in rheumatoid arthritis, pJIA and psoriasis, folic or folinic acid is given to reduce adverse reactions.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnant women with non-neoplastic diseases; methotrexate can cause embryo-fetal toxicity and fetal death. Verify pregnancy status before starting treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Methotrexate: Folate analogue that inhibits dihydrofolic acid reductase, interfering with DNA synthesis, repair and cellular replication; actively proliferating tissues are most sensitive (US label).