سعر ميكارديس بلس 80/25 مجم 28 قرص 2024

Micardis Plus tablets containing telmisartan 80 mg and hydrochlorothiazide 25 mg, pack of 28 (Boehringer Ingelheim), for hypertension.

• Essential hypertension in adults not adequately controlled on MicardisPlus 80 mg/12.5 mg, or previously stabilised on telmisartan and hydrochlorothiazide given separately.Population: Adultselectronic medicines compendium (emc), UK

• The most commonly reported adverse reaction is dizziness; serious angioedema may occur rarely (>= 1/10,000 to < 1/1,000).International label, same product · electronic medicines compendium (emc), UK

• Hypersensitivity to the active substances, excipients or other sulphonamide-derived substances; second and third trimesters of pregnancy; cholestasis and biliary obstructive disorders; severe hepatic impairment; severe renal impairment (CrCl < 30 mL/min) or anuria; refractory hypokalaemia or hypercalcaemia; concomitant aliskiren in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m2).International label, same product · electronic medicines compendium (emc), UK

• Dual blockade of the renin-angiotensin-aldosterone system (ACE inhibitors, angiotensin II receptor blockers or aliskiren) increases the risk of hypotension, hyperkalaemia and reduced renal function.International label, same product · electronic medicines compendium (emc), UK
• An increased risk of non-melanoma skin cancer (basal cell and squamous cell carcinoma) with increasing cumulative hydrochlorothiazide exposure has been observed in epidemiological studies.International label, same product · electronic medicines compendium (emc), UK
• Intestinal angioedema has been reported with angiotensin II receptor blockers (abdominal pain, nausea, vomiting, diarrhoea); patients with primary aldosteronism generally do not respond and use is not recommended.International label, same product · electronic medicines compendium (emc), UK

• LithiumReversible increases in serum lithium and toxicity have been reported with angiotensin II receptor blockers including telmisartan/HCTZ; co-administration is not recommended.electronic medicines compendium (emc), UK
• AliskirenConcomitant aliskiren-containing products are contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m2).electronic medicines compendium (emc), UK

• Angiotensin II receptor blockers should not be initiated during pregnancy; when pregnancy is diagnosed treatment should be stopped immediately and alternative therapy started if appropriate. Contraindicated in the second and third trimesters.International label, same product · electronic medicines compendium (emc), UK
• Not recommended during breast-feeding because no information is available; hydrochlorothiazide is excreted in human milk in small amounts and high-dose thiazides can inhibit milk production.International label, same product · electronic medicines compendium (emc), UK

• Telmisartan: Selective AT1 antagonist blocking angiotensin II vasoconstriction and aldosterone secretion.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.