سعر ميكارديس بلس 40/12.5 مجم 28 قرص 2024

Telmisartan 40 mg + hydrochlorothiazide 12.5 mg tablets, 28 tablets (4 strips) (Micardis Plus, Boehringer Ingelheim).

• Treatment of essential hypertension (40 mg/12.5 mg fixed-dose combination).Population: Adults whose blood pressure is not adequately controlled on telmisartan aloneEuropean Medicines Agency (EMA)

• Most commonly reported: dizziness; serious angioedema may occur rarely. Hydrochlorothiazide-related reactions include electrolyte disturbances and (frequency not known) non-melanoma skin cancer; telmisartan-related reactions include hyperkalaemia, hypotension and renal impairment.International label, same product · European Medicines Agency (EMA)

• Hypersensitivity to the actives, excipients or other sulphonamide-derived substances; second and third trimesters of pregnancy; cholestasis and biliary obstruction; severe hepatic impairment; severe renal impairment (CrCl <30 ml/min) or anuria; refractory hypokalaemia or hypercalcaemia; with aliskiren in diabetes or renal impairment (GFR <60).International label, same product · European Medicines Agency (EMA)

• Non-melanoma skin cancer (basal and squamous cell carcinoma) risk rises with cumulative hydrochlorothiazide dose; advise sun protection and regular skin checks and examine suspicious lesions promptly.International label, same product · European Medicines Agency (EMA)
• Thiazides can cause fluid/electrolyte imbalance (hypokalaemia, hyponatraemia, hypochloraemic alkalosis); check electrolytes periodically. Thiazides may impair glucose tolerance, raise lipids and uric acid (gout); hypoglycaemia may occur in diabetics on insulin or antidiabetics with telmisartan.International label, same product · European Medicines Agency (EMA)
• Telmisartan component: stop when pregnancy is diagnosed; dual RAAS blockade not recommended; risk of hypotension in volume depletion, renovascular hypertension and hyperkalaemia as for other RAAS-acting medicines.International label, same product · European Medicines Agency (EMA)

• Not recommended: no information for telmisartan; hydrochlorothiazide passes into milk in small amounts and high doses can suppress lactation; if used, keep doses as low as possible.International label, same product · European Medicines Agency (EMA)

• Telmisartan: Selective AT1 antagonist blocking angiotensin II vasoconstriction and aldosterone secretion.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.