سعر نيكسبريس 10/320مجم 20 قرص 2026

Nexpress 10/320 mg film-coated tablets (Eva Pharma/Next Pharma, Egypt): fixed-dose amlodipine + valsartan for hypertension; 20 tablets.

• Treatment of hypertension to lower blood pressure in patients not adequately controlled on monotherapy, or as initial therapy in patients likely to need multiple drugs to reach goals.Population: AdultsDailyMed (NLM)

• Adverse events (>=2%, more than placebo): peripheral edema, nasopharyngitis, upper respiratory tract infection and dizziness; peripheral edema and vertigo were the most common reasons for discontinuation.International label, equivalent formulation · DailyMed (NLM)

• Known hypersensitivity to any component; do not co-administer aliskiren in patients with diabetes.International label, equivalent formulation · DailyMed (NLM)

• Fetal toxicity: drugs acting on the renin-angiotensin system in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as pregnancy is detected.International label, equivalent formulation · DailyMed (NLM)
• Hypotension: correct volume depletion before starting (symptomatic hypotension possible in volume- or salt-depleted patients); increased angina and/or myocardial infarction may occur; monitor renal function and potassium in susceptible patients.International label, equivalent formulation · DailyMed (NLM)

• Moderate and strong CYP3A inhibitorsIncrease amlodipine exposure and may require dose reduction; monitor for hypotension and edema.DailyMed (NLM)
• CYP3A inducers (e.g. rifampicin, St John's wort)Monitor blood pressure closely.DailyMed (NLM)
• SildenafilMonitor for hypotension.DailyMed (NLM)

• Can cause fetal harm: renin-angiotensin system drugs in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; oligohydramnios/anhydramnios reported with valsartan; discontinue as soon as pregnancy is detected.International label, equivalent formulation · DailyMed (NLM)
• Limited information on presence in human milk; valsartan is present in rat milk and amlodipine has been reported in human milk; breastfeeding is not recommended during treatment.International label, equivalent formulation · DailyMed (NLM)

• Amlodipine: Inhibits transmembrane influx of calcium ions into vascular smooth and cardiac muscle, causing peripheral arterial vasodilation.
• Valsartan: Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking its binding to the AT1 receptor.