سعر نيرين 50 مجم/5 مل 5 محلول في أمبول للحقن الوريدي 2025

Nyrin 50 mg/5 ml solution in ampoules for IV injection, pack of 5 (Hikma Specialized Pharmaceuticals): calcium folinate (leucovorin/folinic acid) 50 mg per 5 ml (10 mg/ml).

• Calcium folinate rescue: diminish toxicity and counteract folic acid antagonists such as methotrexate in cytotoxic therapy and overdose.Population: Adults and children (per UK SmPC)UK eMC / MHRA
• In combination with 5-fluorouracil in cytotoxic therapy.Population: Adults/elderly; no paediatric combination data in SmPCUK eMC / MHRA

• Very rare: allergic reactions including anaphylactoid/anaphylactic reactions and urticaria. With 5-FU: very common mucositis and enhanced GI/haematological toxicity.International label, same formulation · UK eMC / MHRA

• Hypersensitivity to calcium folinate or excipients; pernicious anaemia or other anaemias due to vitamin B12 deficiency.International label, same formulation · UK eMC / MHRA

• Use with MTX or 5-FU only under experienced oncology supervision. May mask B12-deficiency anaemia. Enhances 5-FU toxicity. Do not mix with 5-FU in the same infusion.International label, same formulation · UK eMC / MHRA

• 5-FluorouracilMajorConcomitant calcium folinate enhances efficacy and toxicity of 5-fluorouracil.UK eMC / MHRA
• Phenobarbital / phenytoin / primidone / succinimidesModerateMay decrease plasma concentrations of these antiepileptics and increase seizure frequency.UK eMC / MHRA

• No adequate studies in pregnancy; no indication that calcium folinate alone induces harmful effects. With MTX or 5-FU follow those agents' restrictions (5-FU combination generally contraindicated in pregnancy/breastfeeding).International label, same formulation · UK eMC / MHRA
• Unknown whether excreted in human milk; may be used during breastfeeding when considered necessary.International label, same formulation · UK eMC / MHRA