سعر اوكتوكونفال 300مجم 30 قرص 2024

Gabapentin 300 mg scored film-coated tablets (Octoconval, October Pharma, Egypt); pack of 30 tablets.

• Most common adverse reactions: postherpetic neuralgia - dizziness, somnolence, peripheral edema; epilepsy (>=12 years) - somnolence, dizziness, ataxia, fatigue, nystagmus.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to gabapentin or its ingredients.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Drug reaction with eosinophilia and systemic symptoms (DRESS)/multiorgan hypersensitivity has been reported; discontinue if an alternative cause cannot be established.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Anaphylaxis and angioedema may occur; discontinue and seek immediate care.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Somnolence, sedation and dizziness may impair the ability to drive or operate machinery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Antiepileptic drugs increase the risk of suicidal thoughts or behavior; monitor for depression, suicidality and unusual mood changes.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Do not stop abruptly in epilepsy because of the risk of increased seizure frequency; withdraw gradually over at least 1 week.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Serious, life-threatening or fatal respiratory depression may occur with concomitant opioids or other CNS depressants, in underlying respiratory impairment and in the elderly.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• In children 3-12 years with epilepsy, neuropsychiatric adverse reactions (emotional lability, hostility, thought disorders, hyperkinesia) have been reported.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Opioids (e.g. morphine, hydrocodone)Risk of respiratory depression and sedation; morphine increased gabapentin exposure, and gabapentin decreased hydrocodone exposure.DailyMed (U.S. National Library of Medicine)
• Aluminum/magnesium hydroxide antacids (e.g. Maalox)Reduce gabapentin bioavailability by about 20%; take gabapentin at least 2 hours after the antacid.DailyMed (U.S. National Library of Medicine)
• Other CNS depressants (including alcohol)Additive CNS depression and risk of respiratory depression.DailyMed (U.S. National Library of Medicine)

• Available human data do not suggest an increased risk of major birth defects, but developmental toxicity was seen in animal studies; patients may enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Gabapentin is secreted in human milk; weigh the benefits of breastfeeding against the mother's need for the drug and possible effects on the infant.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Gabapentin: Structurally related to GABA but does not bind GABA receptors; binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels; the exact mechanism of its anticonvulsant and analgesic effects is unknown.