سعر اوبرانيت 20/1100 مجم 2024

Opranate 20/1100 mg capsule, 10 per pack: immediate-release omeprazole 20 mg buffered with sodium bicarbonate 1100 mg, by Rameda (Egypt).

• Short-term treatment of active duodenal ulcer and active benign gastric ulcer; treatment of heartburn and other GERD symptoms; short-term treatment and maintenance of healing of erosive esophagitis (adults).DailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>2%) with omeprazole: headache, abdominal pain, nausea, diarrhea, vomiting and flatulence.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to any component (including substituted benzimidazoles); co-administration with rilpivirine-containing products.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sodium bicarbonate content: consider sodium load in patients on a sodium-restricted diet; avoid in Bartter's syndrome, hypokalemia, hypocalcemia and acid-base disorders; chronic use with calcium/milk may cause milk-alkali syndrome.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• PPI class warnings: symptomatic response does not exclude gastric malignancy; acute tubulointerstitial nephritis; C. difficile-associated diarrhea; bone fracture with long-term high-dose use; cutaneous and systemic lupus erythematosus; hypomagnesemia; vitamin B12 deficiency with long-term use; fundic gland polyps.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Rilpivirine-containing productsContraindicated: PPIs reduce rilpivirine exposure.DailyMed (U.S. National Library of Medicine)
• ClopidogrelAvoid concomitant use: omeprazole reduces the antiplatelet activity of clopidogrel.DailyMed (U.S. National Library of Medicine)
• Methotrexate (high dose)May elevate and prolong methotrexate levels; consider temporary PPI withdrawal.DailyMed (U.S. National Library of Medicine)

• US label: available epidemiological data with omeprazole in pregnancy do not show an increased risk of major malformations or other adverse outcomes; use the lowest effective dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• US label: omeprazole is present in human milk; consider benefits of breastfeeding against the mother's need and possible infant effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Omeprazole: Suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase (proton pump) of the gastric parietal cell.
• Sodium bicarbonate: Raises gastric pH so acid-labile omeprazole is protected from degradation and absorbed without an enteric coating.