سعر بيبراسيللين-تازوباكتام ساندوز 4.5جم فيال وريد 2022

Piperacillin-Tazobactam Sandoz 4.5 g powder for intravenous infusion, single vial (Sandoz > Novartis Pharma); penicillin with beta-lactamase inhibitor.

• Treatment of intra-abdominal infections and nosocomial pneumonia (adults and children 2 months and older), skin and skin structure infections, female pelvic infections and community-acquired pneumonia (adults) caused by susceptible bacteria.DailyMed (U.S. National Library of Medicine)

• Most common in monotherapy trials: diarrhoea (11.3%), constipation (7.7%), nausea (6.9%), vomiting, dyspepsia, rash and pruritus, fever.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of allergic reactions to any penicillin, cephalosporin or beta-lactamase inhibitor.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious, occasionally fatal hypersensitivity (anaphylactic) reactions; enquire about previous beta-lactam allergy and discontinue if an allergic reaction occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Independent risk factor for renal failure in critically ill patients; consider alternatives and monitor renal function; combined use with vancomycin may increase acute kidney injury.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea has been reported and may range from mild diarrhoea to fatal colitis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• AminoglycosidesPiperacillin may inactivate aminoglycosides; reconstitute and administer separately; monitor aminoglycoside levels in end-stage renal disease.DailyMed (U.S. National Library of Medicine)
• ProbenecidProlongs the half-lives of piperacillin and tazobactam; avoid unless benefit outweighs risk.DailyMed (U.S. National Library of Medicine)
• MethotrexateMay reduce methotrexate clearance; monitor methotrexate levels and toxicity.DailyMed (U.S. National Library of Medicine)

• Piperacillin and tazobactam cross the placenta; data in pregnant women are insufficient to inform risk of major birth defects or miscarriage; no fetal malformations in rats or mice.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Piperacillin is excreted in human milk; tazobactam in milk has not been studied; no information on effects on the breastfed child.International label, same formulation · DailyMed (U.S. National Library of Medicine)