سعر روداك 200 مجم 20 قرص 2023

Sulindac 200 mg oral tablets (NSAID, acetic acid derivative) by Sigma; pack of 20 tablets.

• OsteoarthritisPopulation: AdultsDailyMed (US National Library of Medicine)
• Rheumatoid arthritisPopulation: AdultsDailyMed (US National Library of Medicine)
• Ankylosing spondylitisPopulation: AdultsDailyMed (US National Library of Medicine)

• Most frequent: gastrointestinal pain (about 10%), dyspepsia, nausea with or without vomiting, diarrhoea, constipation, flatulence, anorexia, GI cramps; also rash, pruritus, dizziness, headache, nervousness, tinnitus and oedema.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Less than 1%: gastritis, peptic ulcer and GI bleeding, rare GI perforation; liver function abnormalities, jaundice, cholestasis, hepatitis, hepatic failure; pancreatitis; sulindac metabolites in biliary sludge/calculi.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Known hypersensitivity to sulindac.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• History of asthma, urticaria or allergic-type reactions after aspirin or other NSAIDs (severe, rarely fatal anaphylactic reactions reported).International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Setting of coronary artery bypass graft (CABG) surgery.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Boxed warning: NSAIDs increase the risk of serious cardiovascular thrombotic events (myocardial infarction, stroke), which can be fatal; the risk may occur early in treatment and may increase with duration of use.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Boxed warning: NSAIDs increase the risk of serious gastrointestinal bleeding, ulceration and perforation, which can be fatal and can occur without warning; elderly patients are at greater risk.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• ACE inhibitors / angiotensin II antagonistsNSAIDs may diminish the antihypertensive effect; in elderly, volume-depleted or renally impaired patients the combination may worsen renal function (possible acute renal failure).DailyMed (US National Library of Medicine)
• Diuretics (furosemide, thiazides)NSAIDs can reduce the natriuretic effect of furosemide and thiazides; monitor for renal failure and diuretic efficacy.DailyMed (US National Library of Medicine)
• LithiumNSAIDs raise plasma lithium levels and reduce renal lithium clearance; observe for lithium toxicity.DailyMed (US National Library of Medicine)

• NSAID use can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment; limit dose and duration between about 20 and 30 weeks of gestation and avoid use from about 30 weeks onward.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Not known whether excreted in human milk (secreted in milk of lactating rats); decide whether to discontinue nursing or the drug.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Sulindac: Inhibits prostaglandin synthesis (cyclooxygenase inhibition), mainly through its active sulfide metabolite.