سعر سيداكورون 200مجم 20 اقراص 2022

Sedacoron 200 mg tablets (Sandoz, distributed by B.P Pharma in Egypt), 20 tablets of amiodarone, a class III antiarrhythmic.

• Life-threatening recurrent ventricular fibrillation and recurrent haemodynamically unstable ventricular tachycardia in adults not responding to, or intolerant of, other antiarrhythmics.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Serious adverse reactions include pulmonary toxicity, hepatic injury, worsened arrhythmia, visual impairment, thyroid abnormalities, bradycardia, peripheral neuropathy, photosensitivity and skin discoloration.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Cardiogenic shock; sick sinus syndrome, second- or third-degree AV block, or bradycardia leading to syncope without a functioning pacemaker; known hypersensitivity to amiodarone or any component, including iodine.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: for life-threatening arrhythmias only because of substantial toxicity; pulmonary toxicity (pneumonitis, fatal in about 10% of cases), hepatotoxicity (can be fatal) and worsened arrhythmia can occur.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Can cause hypothyroidism or hyperthyroidism, optic neuropathy/neuritis with possible permanent visual loss, bradycardia, peripheral neuropathy, photosensitivity and skin discoloration; adverse effects and interactions may persist for weeks after stopping because of the long half-life.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• WarfarinPotentiates anticoagulant response with risk of serious or fatal bleeding; reduce warfarin dose by one-third to one-half and monitor prothrombin time.DailyMed (U.S. National Library of Medicine)
• DigoxinIncreases digoxin concentration; reduce digoxin by half or discontinue and monitor for toxicity.DailyMed (U.S. National Library of Medicine)
• Simvastatin, lovastatin, atorvastatinIncreased statin exposure; limit simvastatin to 20 mg and lovastatin to 40 mg; lower starting doses of other CYP3A4-metabolised statins may be needed.DailyMed (U.S. National Library of Medicine)

• Use in pregnancy may increase the risk of fetal adverse effects including neonatal hypo- and hyperthyroidism, neonatal bradycardia, neurodevelopmental abnormalities, preterm birth and fetal growth restriction; amiodarone and desethylamiodarone cross the placenta.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Amiodarone and desethylamiodarone are present in breast milk at 3.5-45% of the maternal weight-adjusted dose; hypothyroidism and bradycardia have been reported in breastfed infants. Breastfeeding is not recommended during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Amiodarone: Prolongs myocardial action potential duration and refractoriness (class III effect), with additional sodium-channel, antisympathetic and calcium-channel-like effects.