سعر سبيرونولاكتون 25مجم 10 اقراص 2022

Generic spironolactone 25 mg oral tablets, 10 per pack, marketed in Egypt by Al Delta Pharmaceuticals Trading (Global Napi Pharmaceuticals); an aldosterone antagonist / potassium-sparing diuretic.

• NYHA class III-IV heart failure with reduced ejection fraction (to increase survival, manage edema and reduce hospitalization).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Add-on therapy for hypertension.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Edema in cirrhosis or nephrotic syndrome when other measures are inadequate.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Reported: gastric bleeding, ulceration, gastritis, diarrhea, cramping, nausea, vomiting; decreased libido, erectile dysfunction, menstrual irregularities, breast pain; electrolyte disturbances; rash and hypersensitivity reactions.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalemia; Addison's disease; concomitant use of eplerenone.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalemia, increased by renal impairment, potassium supplements, potassium-containing salt substitutes, ACE inhibitors or ARBs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Excessive diuresis may cause dehydration, hypotension and worsening renal function; nephrotoxic drugs (aminoglycosides, cisplatin, NSAIDs) may worsen renal function.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May cause hyponatremia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis, hyperglycemia and hyperuricemia (rarely gout).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potassium supplements, salt substitutes, ACE inhibitors, ARBs and other drugs that raise potassiumIncreased risk of hyperkalemia.DailyMed (U.S. National Library of Medicine)
• LithiumDiuretics reduce lithium clearance and increase the risk of lithium toxicity.DailyMed (U.S. National Library of Medicine)
• NSAIDsMay reduce diuretic/antihypertensive effect and increase hyperkalemia risk.DailyMed (U.S. National Library of Medicine)

• Because of potential risk to the male fetus from anti-androgenic properties and animal data, avoid spironolactone in pregnant women or advise of the potential risk to a male fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Spironolactone is not present in breast milk, but its active metabolite canrenone was found in low amounts expected to be clinically inconsequential; long-term infant effects are unknown.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Spironolactone: Spironolactone and its active metabolites competitively antagonise aldosterone at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted tubule, increasing sodium and water excretion while retaining potassium.