سعر ايبلورفيكس 50مجم 7 قرص 2022

Eplerenone 50 mg film-coated tablets, pack of 7 (Hikma Eplorefix).

• Improve survival of stable adult patients with symptomatic heart failure with reduced ejection fraction (<=40%) after an acute myocardial infarction.Population: AdultsDailyMed (U.S. NLM)
• Treatment of hypertension in adults, to lower blood pressure.Population: AdultsDailyMed (U.S. NLM)

• Heart failure post-MI: most common adverse reactions (>2% and more than placebo) were hyperkalemia and increased creatinine; in hypertension trials adverse reactions were uncommon.International label, equivalent formulation · DailyMed (U.S. NLM)

• All patients: serum potassium >5.5 mEq/L at initiation; creatinine clearance <=30 mL/min; concomitant strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, nelfinavir).International label, equivalent formulation · DailyMed (U.S. NLM)
• Hypertension: type 2 diabetes with microalbuminuria; serum creatinine >2.0 mg/dL (males) or >1.8 mg/dL (females); creatinine clearance <50 mL/min; concomitant potassium supplements or potassium-sparing diuretics.International label, equivalent formulation · DailyMed (U.S. NLM)

• Hyperkalemia: risk is higher with impaired renal function, proteinuria, diabetes and concomitant ACE inhibitors, ARBs, NSAIDs or moderate CYP3A inhibitors.International label, equivalent formulation · DailyMed (U.S. NLM)

• Strong CYP3A inhibitorsContraindicated (eplerenone metabolism is predominantly via CYP3A).DailyMed (U.S. NLM)
• Moderate CYP3A inhibitors (e.g., erythromycin, saquinavir, verapamil, fluconazole)Increase exposure; limit eplerenone dose (25 mg once daily post-MI; start 25 mg once daily in hypertension).DailyMed (U.S. NLM)
• ACE inhibitors and angiotensin II receptor blockersIncreased risk of hyperkalemia; monitor potassium and renal function closely.DailyMed (U.S. NLM)

• Published case reports are insufficient to establish a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; no adverse developmental effects in rats and rabbits at high exposures.International label, equivalent formulation · DailyMed (U.S. NLM)
• No human data on presence in milk; eplerenone is present in rat milk, so it is likely to be present in human milk.International label, equivalent formulation · DailyMed (U.S. NLM)

• Eplerenone: Binds the mineralocorticoid receptor and blocks aldosterone binding (Inspra USPI).