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Spironolactone 25 mg tablets, 20 per pack; an aldosterone antagonist (potassium-sparing diuretic).

• NYHA class III-IV heart failure with reduced ejection fraction (survival, edema, hospitalization).DailyMed (US National Library of Medicine)
• Add-on treatment of hypertension.DailyMed (US National Library of Medicine)
• Edema in cirrhosis or nephrotic syndrome when other measures are inadequate.DailyMed (US National Library of Medicine)

• Hyperkalemia; Addison's disease; concomitant use of eplerenone.International label, same formulation · DailyMed (US National Library of Medicine)

• Can cause hyperkalemia, especially with renal impairment, potassium supplements/salt substitutes, ACE inhibitors or ARBs.International label, same formulation · DailyMed (US National Library of Medicine)
• Hypotension and worsening renal function; electrolyte and metabolic abnormalities; gynecomastia.International label, same formulation · DailyMed (US National Library of Medicine)

• Potassium supplements, potassium-containing salt substitutes, ACE inhibitors, ARBsIncreased risk of hyperkalemia.DailyMed (US National Library of Medicine)

• Based on mechanism and animal data, spironolactone may affect sex differentiation of the male fetus; avoid use in pregnancy where possible (US label).International label, same formulation · DailyMed (US National Library of Medicine)
• Active metabolite canrenone found in breast milk in low amounts expected to be clinically inconsequential; long-term infant effects unknown.International label, same formulation · DailyMed (US National Library of Medicine)