سعر سبيكتون 25مجم 20 قرص 2024

Spironolactone 25 mg oral tablets, pack of 20 (2 strips); Kahira Pharmaceuticals, Egypt.

• NYHA class III-IV heart failure with reduced ejection fraction (survival, oedema, hospitalisation).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Add-on treatment of hypertension.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Oedema in cirrhosis or nephrotic syndrome when other measures are inadequate.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Clinically significant: hyperkalaemia, hypotension and worsening renal function, electrolyte/metabolic abnormalities, gynaecomastia, impaired neurological function/coma in cirrhosis with ascites.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalaemia; Addison's disease; concomitant use of eplerenone.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalaemia: risk increased by renal impairment, potassium supplements, potassium-containing salt substitutes, ACE inhibitors or ARBs; reduce dose or stop if it occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Excessive diuresis may cause symptomatic dehydration, hypotension and worsening renal function.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• May cause electrolyte and metabolic abnormalities; monitor serum electrolytes, uric acid and blood glucose periodically.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Potassium supplements, salt substitutes, ACE inhibitors, ARBs, NSAIDs, heparin/LMWH, trimethoprimMay lead to severe hyperkalaemia.DailyMed (U.S. National Library of Medicine)
• LithiumReduced renal lithium clearance; risk of lithium toxicity - monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDsMay reduce the diuretic, natriuretic and antihypertensive effect.DailyMed (U.S. National Library of Medicine)

• Based on mechanism and animal data, spironolactone may affect sex differentiation of the male fetus; limited human case data did not show an association with major malformations.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Spironolactone is not present in breast milk, but its active metabolite canrenone was found in low amounts expected to be clinically inconsequential; long-term infant effects unknown.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Spironolactone: Specific pharmacologic antagonist of aldosterone acting mainly at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule (US label).