سعر سبيكتون 100مجم 20 قرص 2025

Spectone spironolactone 100 mg tablets, pack of 20; Kahira, Egypt. Potassium-sparing diuretic.

• NYHA class III-IV heart failure with reduced ejection fraction (to increase survival, manage oedema and reduce hospitalisation).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Add-on therapy for hypertension.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Oedema in hepatic cirrhosis or nephrotic syndrome not responsive to other measures.Population: AdultsDailyMed (U.S. National Library of Medicine)

• GI bleeding, ulceration, gastritis, diarrhoea, cramps, nausea, vomiting; decreased libido, erectile dysfunction, menstrual irregularities, breast pain; leukopenia/agranulocytosis, thrombocytopenia; hypersensitivity reactions and rashes; electrolyte disturbances; leg cramps; lethargy, confusion, ataxia, dizziness, headache, drowsiness; rare hepatotoxicity; renal dysfunction.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalaemia; Addison's disease; concomitant use of eplerenone.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalaemia (risk increased by renal impairment, potassium supplements/salt substitutes, ACE inhibitors, ARBs).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Excessive diuresis may cause dehydration, hypotension and worsening renal function.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyponatraemia, hypomagnesaemia, hypocalcaemia, hypochloraemic alkalosis, hyperglycaemia and hyperuricaemia/gout may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potassium supplements and drugs increasing potassium (ACE inhibitors, ARBs, NSAIDs, heparin/LMWH, trimethoprim)Risk of severe hyperkalaemia.DailyMed (U.S. National Library of Medicine)
• LithiumReduced lithium clearance; risk of lithium toxicity; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDsMay reduce diuretic, natriuretic and antihypertensive effects.DailyMed (U.S. National Library of Medicine)

• Based on mechanism and animal data, may affect sex differentiation of the male fetus (feminisation in rats); limited human data show no association with major malformations. Avoid in pregnancy or advise of the potential risk to a male fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• The active metabolite canrenone was found in breast milk in low, likely clinically inconsequential amounts; weigh the benefits of breastfeeding against maternal need and potential infant effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Spironolactone: Aldosterone antagonist (mineralocorticoid receptor); increases sodium and water excretion while conserving potassium; also has antiandrogenic activity.