سعر كارفالون 50 مجم 2025

Carfalone 50 mg film-coated tablets (eplerenone), Marcyrl; pack of 20.

• Improve survival in stable adults with symptomatic HFrEF (LVEF <=40%) after acute MI.Population: Adults post-MI HFrEFDailyMed INSPRA (Viatris)
• Treatment of hypertension in adults to lower blood pressure.Population: Adults with hypertensionDailyMed INSPRA (Viatris)

• HFrEF post-MI: most common ARs more frequent than placebo — hyperkalemia and increased creatinine.International label, equivalent formulation · DailyMed INSPRA (Viatris)

• Serum potassium >5.5 mEq/L at initiation; CrCl <=30 mL/min; concomitant strong CYP3A inhibitors.International label, equivalent formulation · DailyMed INSPRA (Viatris)
• For hypertension: type 2 diabetes with microalbuminuria; serum creatinine >2.0 mg/dL (males) or >1.8 (females); CrCl <50 mL/min; potassium supplements or potassium-sparing diuretics.International label, equivalent formulation · DailyMed INSPRA (Viatris)

• Hyperkalemia risk higher with decreased renal function, diabetes, proteinuria, ACE/ARB, NSAIDs, or moderate CYP3A inhibitors; monitor and adjust dose.International label, equivalent formulation · DailyMed INSPRA (Viatris)

• Strong CYP3A inhibitors (e.g. ketoconazole, clarithromycin, ritonavir)MajorContraindicated: strong CYP3A inhibitors markedly increase eplerenone exposure.DailyMed INSPRA (Viatris)
• ACE inhibitors / ARBsModerateIncreased hyperkalemia risk; monitor potassium and renal function closely.DailyMed INSPRA (Viatris)
• NSAIDsModerateMay reduce antihypertensive effect and cause severe hyperkalemia in renal impairment; monitor BP and potassium.DailyMed INSPRA (Viatris)

• Published human pregnancy data insufficient to establish drug-associated risk of major birth defects or miscarriage; animal studies at high multiples of human exposure showed no teratogenicity (decreased fetal weights at high doses).General active-ingredient information · DailyMed INSPRA (Viatris)
• No human data on presence in milk; present in rat milk — likely present in human milk.General active-ingredient information · DailyMed INSPRA (Viatris)

• Eplerenone: Blocks aldosterone binding at mineralocorticoid receptors (US Inspra label).