سعر سبرافاتو 28مجم بخاخ انف 2 جرعة 2024

Spravato (esketamine) 28 mg nasal spray, one single-use device delivering two sprays, by Janssen; NMDA-receptor antagonist antidepressant given under healthcare supervision.

• Treatment-resistant depression in adultsPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behaviour (with an oral antidepressant)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=5% and at least twice placebo) in TRD: dissociation, dizziness, nausea, sedation, vertigo, hypoaesthesia, anxiety, lethargy, increased blood pressure, vomiting, feeling drunk and headache. In MDD with acute suicidal ideation: dissociation, dizziness, sedation, increased blood pressure, hypoaesthesia, vomiting, euphoric mood and vertigo.International label, same product · DailyMed (U.S. National Library of Medicine)

• Aneurysmal vascular disease (including thoracic and abdominal aorta, intracranial and peripheral arterial vessels) or arteriovenous malformation; history of intracerebral haemorrhage; hypersensitivity to esketamine, ketamine or any excipient.International label, same product · DailyMed (U.S. National Library of Medicine)

• Boxed warning: sedation, dissociation, respiratory depression, abuse and misuse, and suicidal thoughts and behaviours (antidepressants increase this risk in children and young adults). Blood pressure increases (risk with cardiovascular/cerebrovascular disease); cognitive impairment; do not drive or operate machinery until the next day after restful sleep; ulcerative or interstitial cystitis; embryo-fetal toxicity.International label, same product · DailyMed (U.S. National Library of Medicine)

• CNS depressants (benzodiazepines, opioids, alcohol)May increase sedation; monitor closely.DailyMed (U.S. National Library of Medicine)
• Psychostimulants (amphetamines, methylphenidate, modafinil, armodafinil)May increase blood pressure; monitor blood pressure closely.DailyMed (U.S. National Library of Medicine)
• Monoamine oxidase inhibitors (MAOIs)May increase blood pressure; monitor blood pressure closely.DailyMed (U.S. National Library of Medicine)

• Not recommended during pregnancy; insufficient human data; based on animal findings with ketamine it may cause fetal harm. Discontinue if pregnancy occurs; consider pregnancy planning and prevention in females of reproductive potential.International label, same product · DailyMed (U.S. National Library of Medicine)
• Esketamine is present in human milk; because of potential neurotoxicity, breastfeeding is not recommended during treatment.International label, same product · DailyMed (U.S. National Library of Medicine)

• Esketamine (as hydrochloride): Esketamine, the S-enantiomer of ketamine, is a non-competitive NMDA receptor antagonist; the mechanism of its antidepressant effect is unknown.