سعر ثيوفيللين Theophylline‏ 200مجم اس ار 20 قرص 2026

Theophylline 200mg S.R. 20 Tab: theophylline 200 mg sustained-release tablet (Amriya, Egypt); methylxanthine bronchodilator.

• At peak serum concentrations <20 mcg/mL: mainly transient caffeine-like effects (nausea, vomiting, headache, insomnia). Above 20 mcg/mL: persistent vomiting, cardiac arrhythmias and intractable seizures, which can be lethal.International label, equivalent formulation · DailyMed (US NLM)

• Hypersensitivity to theophylline or other components of the product.International label, equivalent formulation · DailyMed (US NLM)

• Use with extreme caution in active peptic ulcer disease, seizure disorders and cardiac arrhythmias (not bradyarrhythmias).International label, equivalent formulation · DailyMed (US NLM)
• Many conditions (age >60, CHF, hepatic disease, fever, smoking cessation, interacting drugs) reduce clearance; dose must be reduced to avoid serious toxicity.International label, equivalent formulation · DailyMed (US NLM)

• CiprofloxacinDecreases theophylline clearance (about 40% increase in serum theophylline per US label).DailyMed (US NLM)
• Clarithromycin / erythromycinDecrease theophylline clearance (about 25% increase with clarithromycin per US label).DailyMed (US NLM)
• FluvoxamineDecreases theophylline clearance (similar to cimetidine per US label).DailyMed (US NLM)

• Older-format US label: theophylline was teratogenic in mice, rats and rabbits during organogenesis; clearance changes in pregnancy (reduced in third trimester).International label, equivalent formulation · DailyMed (US NLM)
• Excreted into breast milk at about the maternal serum concentration; may cause irritability or mild toxicity in the nursing infant.International label, equivalent formulation · DailyMed (US NLM)

• Theophylline: Relaxes airway smooth muscle; bronchodilation thought to involve phosphodiesterase (PDE III, to a lesser extent PDE IV) inhibition (US label; mechanism not known with certainty).