سعر تيجاجلور Tigaglor‏ 400مجم 28 اقراص 2026

Oral tablet containing sofosbuvir 400 mg (HCV NS5B polymerase inhibitor), pack of 28 tablets, marketed in Egypt by Organopharma.

• When used with ribavirin or peginterferon alfa/ribavirin, all contraindications of those agents apply to the combination.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Test all patients for current or prior HBV infection (HBsAg and anti-HBc) before starting; HBV reactivation, sometimes fulminant, has been reported in HCV/HBV co-infected patients.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Serious symptomatic bradycardia may occur when amiodarone is co-administered with a sofosbuvir-containing regimen; co-administration is not recommended.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• AmiodaroneSerious symptomatic bradycardia; co-administration not recommended, cardiac monitoring if no alternative.DailyMed (U.S. National Library of Medicine)
• P-gp inducers (e.g. rifampin, St John's wort)May significantly decrease sofosbuvir concentrations and reduce efficacy; use not recommended.DailyMed (U.S. National Library of Medicine)

• If used with ribavirin (with or without peginterferon), the regimen is contraindicated in pregnant women and in men whose partners are pregnant; no adequate human data exist for sofosbuvir alone and animal studies showed no adverse developmental outcomes.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether sofosbuvir or its metabolites are present in human milk; the main metabolite was found in rat milk without effect on pups.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)