سعر اكسين 150 مجم 20 كبسولة 2022

Nizatidine 150 mg capsules, pack of 20 (2 strips); histamine H2-receptor antagonist (Future Pharmaceutical Industries, Egypt).

• Active duodenal ulcer (up to 8 weeks)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Maintenance therapy after healing of duodenal ulcerPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Erosive and ulcerative oesophagitis and associated heartburn due to GERD (up to 12 weeks)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Adverse events reported in placebo-controlled trials included headache, abdominal pain, diarrhoea, nausea, rhinitis and dizziness at rates similar to placebo; anaemia and urticaria were significantly more common than with placebo.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Rare: hepatocellular or cholestatic liver injury, reversible mental confusion, thrombocytopenia, gynaecomastia, sweating, exfoliative dermatitis, vasculitis and anaphylaxis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to nizatidine or history of hypersensitivity to other H2-receptor antagonists (cross-sensitivity observed).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Symptomatic response does not preclude gastric malignancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Reduce dose in moderate to severe renal insufficiency; false-positive urobilinogen tests with Multistix may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Aspirin (very high doses, 3,900 mg/day)Serum salicylate levels increased when nizatidine 150 mg twice daily was co-administered.DailyMed (U.S. National Library of Medicine)
• Drugs metabolised by cytochrome P450 (e.g. theophylline, warfarin, phenytoin, lidocaine, lorazepam)No interactions observed; nizatidine does not inhibit CYP450-mediated metabolism.DailyMed (U.S. National Library of Medicine)

• Animal studies showed no harm to the fetus, but there are no adequate and well-controlled studies in pregnant women; use in pregnancy only if clearly needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• About 0.1% of an oral dose is secreted in human milk; because of growth depression in pups of treated rats, decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nizatidine: Competitive, reversible inhibitor of histamine at H2 receptors of the gastric parietal cells, reducing gastric acid secretion; does not inhibit the cytochrome P450 system.