سعر بيوجليتا بلس Bioglita Plus‏ 15/500 مجم 30 قرص 2026

Bioglita Plus 15/500Mg 30 F.C.Tab (30 film-coated tablets), antidiabetic marketed in Egypt by Andalous Pharma.

• Established NYHA Class III or IV heart failure at initiation; severe renal impairment (eGFR < 30 mL/min); serious hypersensitivity to pioglitazone, metformin or excipients; acute or chronic metabolic acidosis including diabetic ketoacidosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: thiazolidinediones including pioglitazone cause or exacerbate congestive heart failure; monitor for weight gain, dyspnea and edema after initiation and dose increases. Boxed warning: postmarketing cases of metformin-associated lactic acidosis, sometimes fatal; risk increases with renal impairment, contrast agents, surgery, hypoxia, excess alcohol and hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP2C8 inhibitors (e.g. gemfibrozil)Increase pioglitazone exposure; limit pioglitazone dose per label.DailyMed (U.S. National Library of Medicine)
• Carbonic anhydrase inhibitors (e.g. topiramate) and iodinated contrast agentsMay increase risk of lactic acidosis with metformin.DailyMed (U.S. National Library of Medicine)

• Limited data with pioglitazone/metformin or pioglitazone in pregnant women are insufficient to determine drug-associated risk; published metformin studies have not shown a clear association with major birth defects or miscarriage; poorly controlled diabetes carries maternal and fetal risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on pioglitazone in human milk; limited studies show metformin is present in human milk. Weigh breastfeeding benefits against maternal need and potential infant effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Metformin hydrochloride: Decreases hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity.
• Pioglitazone: PPAR-gamma agonist that decreases insulin resistance in the periphery and liver.