سعر بيستول 5 مجم 20 قرص 2025

Bistol 5 mg film-coated tablets, 20 tablets (bisoprolol fumarate); Hikma Pharma; price 34.00 EGP (prev 22.00; updated 2025-07-08); barcode 6221000000195.

• Treatment of hypertension; also used for chronic stable angina and stable chronic heart failure with reduced systolic function as part of guideline-directed therapy (EU bisoprolol SmPC class — confirm exact Egyptian labelled indications on leaflet).Population: AdultsMHRA eMC

• Common/class effects: bradycardia, fatigue, dizziness, headache, feeling of cold extremities; GI symptoms. Combo: additional thiazide effects (electrolyte disturbance, hyperuricaemia).International label, same formulation · MHRA eMC

• Hypersensitivity to bisoprolol or excipients; acute heart failure or decompensation requiring IV inotropes; cardiogenic shock; 2nd/3rd-degree AV block without pacemaker; sick sinus syndrome; sinoatrial block; symptomatic bradycardia; severe bronchial asthma; severe PAD or Raynaud; untreated phaeochromocytoma; metabolic acidosis.International label, same formulation · MHRA eMC

• Do not stop abruptly (risk of rebound). Caution in diabetes (may mask hypoglycaemia), first-degree AV block, Prinzmetal angina, peripheral arterial disease, strict fasting, ongoing desensitisation therapy. Monitor heart rate/BP. Combination with verapamil/diltiazem-type calcium antagonists not recommended.International label, same formulation · MHRA eMC

• Verapamil / diltiazem-type calcium antagonistsMajorNot recommended: negative inotropy and AV conduction; IV verapamil may cause profound hypotension and AV block.MHRA eMC
• Insulin and oral antidiabeticsModerateEnhanced hypoglycaemia; symptoms may be masked by beta-blockade.MHRA eMC
• Centrally acting antihypertensives (e.g. clonidine)MajorNot recommended: bradycardia/reduced output; rebound hypertension on abrupt clonidine withdrawal.MHRA eMC

• Not recommended in pregnancy unless clearly necessary; beta-blockers may reduce placental perfusion; neonatal hypoglycaemia/bradycardia possible. Thiazides (if combo) also generally avoided in pregnancy.International label, same formulation · MHRA eMC
• Not recommended during breastfeeding (bisoprolol excretion uncertain; HCTZ passes into milk and may reduce milk production).International label, same formulation · MHRA eMC

• Bisoprolol fumarate: Highly beta-1-selective adrenoceptor blocker without intrinsic sympathomimetic or relevant membrane-stabilising activity; reduces heart rate, contractility and sympathetic drive.