سعر نبيمون 5مجم 10 اقراص 2022

Nebimoun 5mg 10 f.c. tab: nebivolol 5 mg film-coated tablets, 10 per pack (Amoun); selective beta-1 blocker used for hypertension.

• Hypertension, to lower blood pressure (alone or with other antihypertensives).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions: headache and fatigue.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Severe bradycardia; heart block greater than first degree; cardiogenic shock; decompensated cardiac failure; sick sinus syndrome without a permanent pacemaker; severe hepatic impairment (Child-Pugh >B); hypersensitivity to any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Do not stop abruptly in coronary artery disease (risk of severe angina, MI, ventricular arrhythmias); taper over 1-2 weeks.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• May mask warning signs of hypoglycaemia (e.g. tachycardia) and of hyperthyroidism; patients with bronchospastic disease should generally not receive beta-blockers; may aggravate peripheral vascular disease; in pheochromocytoma start an alpha-blocker first.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Monitor ECG and blood pressure with verapamil- or diltiazem-type calcium channel blockers; CYP2D6 inhibitors increase nebivolol exposure and the dose may need reduction.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine)May increase nebivolol levels; use with caution.DailyMed (U.S. National Library of Medicine)
• Other beta-blockers; reserpine, guanethidine; clonidineDo not combine with other beta-blockers; catecholamine-depleting drugs may cause excessive reduction of sympathetic activity; with clonidine, stop nebivolol several days before tapering clonidine.DailyMed (U.S. National Library of Medicine)
• Digitalis glycosidesBoth slow AV conduction and heart rate; increased risk of bradycardia.DailyMed (U.S. National Library of Medicine)

• Available human data are insufficient to determine drug-associated risk; poorly controlled hypertension in pregnancy carries maternal and fetal risks; embryofetal and perinatal lethality occurred in rats at about the maximum recommended human dose.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk (present in rat milk); because of potential serious adverse reactions in nursing infants (especially bradycardia), breastfeeding is not recommended.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Nebivolol: Beta-adrenergic receptor blocker; per the US BYSTOLIC label the antihypertensive mechanism is not definitively established (reduced heart rate and contractility, suppression of renin activity, reduced sympathetic outflow and vasodilation have been proposed).