سعر دوفاكسيمين 550 مجم 28 قرص مغلف 2024

Dufaximin 550 mg 28 f.c. tabs. — rifaximin 550 mg FC tablets (AUG Pharma).

• Travelers' diarrhea (TD) caused by noninvasive strains of E. coli in patients ≥12 years; reduction in risk of overt hepatic encephalopathy (HE) recurrence in adults; treatment of IBS with diarrhea (IBS-D) in adults (US Xifaxan).DailyMed / FDA

• Common reactions vary by indication (e.g., flatulence, headache, nausea, abdominal pain, elevated ALT, peripheral edema — see full US label) (US Xifaxan).International label, same formulation · DailyMed / FDA

• History of hypersensitivity to rifaximin, any rifamycin antimicrobial, or any component of Xifaxan (US Xifaxan).International label, same formulation · DailyMed / FDA

• TD: do not use if diarrhea is complicated by fever or blood in stool, or due to pathogens other than E. coli. Clostridium difficile-associated diarrhea reported. Severe hepatic impairment: systemic exposure may increase. Concomitant P-gp inhibitors may increase exposure (US Xifaxan).International label, same formulation · DailyMed / FDA

• P-glycoprotein inhibitors (e.g., cyclosporine)MajorMay substantially increase rifaximin systemic exposure (US Xifaxan).DailyMed / FDA
• WarfarinModerateINR changes reported; monitor INR/prothrombin time (US Xifaxan).DailyMed / FDA

• Available data with Xifaxan use in pregnant women are insufficient to inform a drug-associated risk; animal data showed fetal harm at exposures above clinical — advise of potential risk (US Xifaxan PLLR summary).International label, same formulation · DailyMed / FDA

• Rifaximin: Binds bacterial DNA-dependent RNA polymerase beta-subunit, inhibiting transcription and bacterial protein synthesis; minimal systemic absorption after oral dosing.