سعر انيجي 10/10 مجم 14 قرص 2022

Inegy 10 mg/10 mg tablets (MSD; distributed in Egypt via Global Napi Pharmaceuticals), 14 tablets: fixed-dose ezetimibe + simvastatin for lowering LDL cholesterol.

• Adjunct to diet to reduce elevated LDL-C in adults with primary hyperlipidaemia and in adults and children >=10 years with heterozygous familial hypercholesterolaemia.DailyMed (U.S. National Library of Medicine)
• Adjunct to other LDL-C-lowering therapies in adults with homozygous familial hypercholesterolaemia.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Common (>=2% and greater than placebo): headache, increased ALT, myalgia, upper respiratory tract infection and diarrhoea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant strong CYP3A4 inhibitors; concomitant cyclosporine, danazol or gemfibrozil; acute liver failure or decompensated cirrhosis; hypersensitivity to simvastatin, ezetimibe or excipients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis (risk increases with dose and interacting drugs), immune-mediated necrotizing myopathy, hepatic dysfunction, and increases in HbA1c and fasting glucose.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors, cyclosporine, danazol, gemfibrozil, grapefruit juiceIncrease the risk of myopathy and rhabdomyolysis (some are contraindicated).DailyMed (U.S. National Library of Medicine)
• CholestyramineDecreases ezetimibe exposure.DailyMed (U.S. National Library of Medicine)
• Coumarin anticoagulantsObtain INR before initiation and monitor during dose initiation or adjustment.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognized (or consider ongoing therapeutic needs); may cause fetal harm based on mechanism of action; treatment of hyperlipidaemia is generally not necessary during pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk; other statins pass into milk; because of potential serious adverse reactions in the breastfed infant, breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and related phytosterols.
• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis.